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Skin allergy-resisting cosmetic composition

A cosmetic composition, a technology for skin allergy, applied in the directions of cosmetics, cosmetic preparations, preparations for skin care, etc., to achieve the effects of improving mast cell protection and anti-inflammatory soothing effects, good anti-inflammatory soothing effects, and enhancing skin barrier

Active Publication Date: 2018-10-19
YANGSHENGTANG (ANJI) COSMETICS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the current cosmetics, there is a lack of anti-inflammatory soothing products that can effectively protect mast cells and inhibit the release of inflammatory mediators

Method used

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  • Skin allergy-resisting cosmetic composition
  • Skin allergy-resisting cosmetic composition
  • Skin allergy-resisting cosmetic composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: prepare the spray A of anti-skin allergy

[0033] In this example, anti-sensitizer spray A of the present invention having the following formulation was prepared.

[0034]

[0035] The preparation procedure of above-mentioned spray A is as follows:

[0036] (1) Heat water to 80°C, add allantoin, glycerin, panthenol, betaine in sequence, mix, stir and dissolve evenly;

[0037] (2) Cool the above mixture to 40°C, add oat kernel extract, and discharge.

[0038] The resulting spray A was a pale yellow clear liquid.

Embodiment 2

[0039] Example 2 (Comparative): Preparation of Control Sprays B, C, D and E

[0040] In this example, using a procedure similar to that above, control sprays B, C, D and E were prepared with the following formulations, all of which did not contain the combination of panthenol, allantoin and oat kernel extract . Among them, the obtained spray B is a colorless clear liquid, and the sprays C, D, and E are light yellow clear liquids.

[0041]

Embodiment 3

[0042] Embodiment 3. The influence of spray A-E on RBL-2H3 cell hypersensitivity

[0043] The effects of the sprays A-E prepared above on the allergic response of cells were tested according to the method described below.

[0044] Experimental principle: Compound 48 / 80 is a tool drug that causes mast cell degranulation. Its mechanism is to act on the mast cell membrane, causing an increase in intracellular calcium ions, thereby changing the amount of the second messenger cAMP and cGMP, leading to mast cell degranulation. particles and release histamine.

[0045] Experimental materials: Cell RBL-2H3 cell line was provided by the Animal Center of Zhejiang Academy of Medical Sciences; test samples included the above-mentioned 5 sprays A-E; reagents included fetal bovine serum, RPM1640 medium, benchtop salt (mainly composed of sodium chloride, phosphate, Calcium chloride, glucose, etc.), compound 48 / 80, histamine Elisa kit.

[0046] Experimental steps:

[0047]

[0048] Expe...

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PUM

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Abstract

The invention relates to application of a composition of D-panthenol, allantoin and an oat kernel extract in protecting mast cells and further resisting skin allergy. The invention also provides a skin allergy-resisting cosmetic composition with the effect of protecting the mast cells; the allergy-resisting cosmetic composition is prepared from the composition of the D-panthenol, the allantoin andthe oat kernel extract as well as ingredients commonly used in cosmetic compositions; besides, the invention provides a skin allergy-resisting beauty method which includes the application of the cosmetic composition to the skin.

Description

technical field [0001] The present invention belongs to the field of cosmetics, more specifically, the present invention relates to a kind of anti-skin allergy cosmetic composition with the function of protecting mast cells, which comprises the combination of D-panthenol, allantoin and oat kernel extract, and the cosmetic composition commonly used ingredients. Background technique [0002] Due to the deterioration of the environment, the increase of life and work pressure, and excessive skin cleaning, more and more people's skin barrier is damaged, and inflammatory symptoms such as skin erythema, itching, and tingling begin to appear. At the same time, improper use of cosmetics aggravates these symptoms. Therefore, there is an urgent need for cosmetics with obvious anti-inflammatory effect, safety, and no adverse reactions to relieve allergic symptoms. [0003] Mast cells are widely distributed around the microvessels under the skin and visceral mucosa, and their cells con...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/42A61K8/49A61K8/9794A61Q19/00A61P37/08
CPCA61P37/08A61Q19/00A61K8/42A61K8/4946A61K8/9794A61K2800/10A61K8/73A61Q19/005A61Q17/00A61K8/673A61K8/445A61K36/899A61P17/02A61P17/00A61K2800/5922A61K2800/522A61K2800/591
Inventor 温轶吴瑞雪郑小微宁新娟
Owner YANGSHENGTANG (ANJI) COSMETICS CO LTD
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