A compound tannic acid antidote for f-2 toxin poisoning and its application

An antidote, F-2 technology, applied in the direction of antidote, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problem of enhancing the activity of poisoned ovarian granulosa cells in the detoxification effect, the detoxification effect is not significant enough, and the F-2 toxin detoxification The effect is not comprehensive enough to achieve the effect of improving animal production performance, improving the immune function of the body, and repairing anti-oxidative damage

Active Publication Date: 2021-07-13
CHANGSHA LVYE BIOTECHNOLOGY CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The antidote of the F-2 toxin disclosed in the prior art is vitamin-E (V-E). Although V-E has a detoxification effect on the F-2 toxin, its detoxification effect is limited to enhancing the activity of poisoned ovarian granulosa cells and reducing the number of cells. Malondialdehyde (MDA) content, the detoxification effect of V-E on F-2 toxin is not comprehensive enough, and the detoxification effect is not significant enough

Method used

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  • A compound tannic acid antidote for f-2 toxin poisoning and its application
  • A compound tannic acid antidote for f-2 toxin poisoning and its application
  • A compound tannic acid antidote for f-2 toxin poisoning and its application

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preparation example Construction

[0019] The present invention provides a preparation method of an antidote for F-2 toxin poisoning described in the above technical proposal, comprising the following steps: mixing tannic acid, astragalus polysaccharide, glycyrrhizin, and mulberry extract, grinding and drying to obtain Antidote for F-2 toxin poisoning. The present invention has no specific limitation on the grinding method, the particle size of the ground material, the drying method and the water content of the antidote after drying.

[0020] The present invention provides the application of the antidote for F-2 toxin poisoning described in the above technical scheme in the preparation of animal medicine for F-2 toxin poisoning.

[0021] The present invention provides the application of the antidote for F-2 toxin poisoning described in the above technical solution in the preparation of drugs for inhibiting the expression of estrogen receptors in vivo; the estrogen receptors are preferably ERα or ERβ.

[0022] ...

Embodiment 1

[0025] According to the weight ratio of tannic acid: astragalus polysaccharide: glycyrrhizin: mulberry extract = 3:1:1:1, the mixture is ground into powder to obtain the antidote for F-2 toxin poisoning.

[0026] When pigs are poisoned by F-2 toxin, add 0.05-0.1% of the above-mentioned antidote to the ration by weight, stir evenly and then feed.

Embodiment 2

[0028] According to the weight ratio of tannic acid: astragalus polysaccharide: glycyrrhizin: mulberry extract = 47: 15: 15: 15, the mixture is ground into powder to obtain the antidote for F-2 toxin poisoning.

[0029] In order to verify the detoxification effect of the antidote of the present invention on F-2 toxin poisoning, the following test is carried out: 24 Du × long × large three-way hybrid young sows are divided into 4 groups, 6 repetitions in each group, and 1 head in each repetition pig. Control group (normal diet), poisoning group (containing 240 μg / kg F-2 toxin in the diet), treatment group 1 (containing 240 μg / kg F-2 toxin+accounting for 0.1% tannin in the diet weight in the diet) acid), treatment group 2 (240 μg / kg F-2 toxin+accounting for 0.1% antidote of the present invention by weight in the diet), and the test time was 24 days. After the start of the experiment, observe and record the swelling of the vulva of the pigs every day, measure the length (a) and ...

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Abstract

The invention provides a compound tannic acid antidote for F-2 toxin poisoning and its application, and belongs to the technical field of F-2 toxin poisoning antidote. The antidote is prepared from raw materials comprising the following parts by weight: tannin 40-50 parts of acid, 10-20 parts of astragalus polysaccharide, 10-20 parts of glycyrrhizin, 10-20 parts of mulberry extract. The antidote of the present invention uses tannic acid as the main component, and is equipped with astragalus polysaccharide, glycyrrhizin and mulberry extract, which can not only effectively inhibit the expression of estrogen receptors in the body, but also antagonize the estrogen-like toxic effect of F-2 toxin ; At the same time, it can also repair anti-oxidative damage and improve the immune function of the body, so as to fully and effectively antagonize the toxicity of F-2 toxin, thereby improving animal production performance.

Description

technical field [0001] The invention relates to the technical field of F-2 toxin poisoning antidote, in particular to a compound tannic acid antidote for F-2 toxin poisoning. Background technique [0002] F-2 toxin, also known as Zearalenone (ZEA), is a secondary metabolite produced by Fusarium graminearum, Gibberella zea and other molds, and has certain toxicity. Widely present in some cereal crops, such as corn, sorghum and wheat, especially corn and its by-products. F-2 toxin can cause strong pollution to feed raw materials and feed itself, thus causing serious harm to animal organisms. F-2 toxin has an estrogen-like effect, which can affect the reproductive function of animals, among which pigs are the most sensitive. F-2 toxin enters the body and is mainly distributed in tissues and organs rich in estrogen receptors, such as Leydig cells, follicles and uterus etc. When sows are poisoned, they mainly appear redness and swelling of vulva, uterine hyperemia and hyperpla...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/605A61P39/02A61K31/7024A61K31/715A61K31/704
CPCA61K31/7024A61K31/704A61K31/715A61K36/605A61P39/02A61K2300/00
Inventor 邬静易金娥文利新袁志航屠迪
Owner CHANGSHA LVYE BIOTECHNOLOGY CO LTD
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