Pancreas cancer personalized prognosis evaluation method based on multi-gene expression characteristic spectrum

Abstract

The invention discloses a pancreas cancer personalized prognosis evaluation method based on multi-gene expression characteristic spectrum. The pancreas cancer personalized prognosis evaluation methodbased on multi-gene expression characteristic spectrum includes the following steps: acquiring a pancreas cancer prognosis risk gene list and gene weight; constructing a prognosis evaluation model bymeans of pancreas cancer patient tumour tissue transcriptome and survival data; according to the gene expression spectrum of the pancreas cancer patient tumour tissue, calculating the risk score of the patient; and according to the risk score of the patient, calculating the annual survival probability of the patient. The annual survival probability of the pancreatic cancer patient, obtained through the pancreas cancer personalized prognosis evaluation method based on multi-gene expression characteristic spectrum is highly consistent with the actual annual survival rate (linear correlation R2 =0.980, P value = 9.76E-17). Therefore, it is proved that the pancreas cancer personalized prognosis evaluation method based on multi-gene expression characteristic spectrum has very high prediction accuracy, and highly matches the practical survival state. At the same time, for each tumour patient, the pancreas cancer personalized prognosis evaluation method based on multi-gene expression characteristic spectrum can provide a special survival probability curve for the patient.

Description

technical field [0001] The invention belongs to the fields of biotechnology and medicine, and in particular relates to a method for evaluating the individualized prognosis of pancreatic cancer based on a polygene expression profile. Background technique [0002] Pancreatic cancer is a malignant tumor with high risk worldwide. Pancreatic cancer patients generally have a short average survival time. Statistics show that the number of deaths from pancreatic cancer in men and women in the world differs little. Global Burden of Disease (GBD) data shows that in 2016, the number of people suffering from pancreatic cancer worldwide was 360,000, of which 57,000 were in China. In 2016, the number of deaths of pancreatic cancer patients worldwide was 410,000, accounting for 0.74% of the total deaths. In 2016, the number of patients who died in China exceeded 72,000, accounting for 0.74% of the total number of deaths. The statistical results show that from 1990 to 2016, the prevalen...

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Problems solved by technology

However, most reports only use single or several genes, can only classify a group, and can only qualitatively divide the individual survival period (such as two indicators of good prognosis and poor prognosis)

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