Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Quality control method of Jichuanjian composition

A quality control method and composition technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of few indicators, many components, single quality control, etc., and achieve the effect of convenient operation, objective conclusion, and quality control of preparations

Active Publication Date: 2021-01-29
CHINA RESOURCES SANJIU MEDICAL & PHARMA
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Therefore, the technical problem to be solved in the present invention is to overcome the traditional Chinese medicine compound preparations in the prior art, which basically only have one or two index components in content control, single quality control, few indexes, and it is difficult to fully reflect that there are many flavors and many components. , the defects of the quality status of the Jichuan fried composition with many targets, thereby providing a quality control method for the Jichuan fried composition

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Quality control method of Jichuanjian composition
  • Quality control method of Jichuanjian composition
  • Quality control method of Jichuanjian composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Example 1. Preparation of Jichuan Fried Composition

[0066] According to the following proportions, take 625g of Cistanche deserticola; 1000g of angelica; 500g of Achyranthes bidentata; 375g of Alisma alisma; Filtrate, concentrate the filtrate to a clear paste with a relative density of 1.20-1.25 (60° C.), add an appropriate amount of maltodextrin, mix well, dry, and granulate to make 1000 g of Jichuan decoction composition.

Embodiment 2

[0067] Example 2. Research on the Fingerprint of Jichuan Fried Composition

[0068] Instruments and reagents

[0069] High performance liquid chromatography: Agilent 1100Series;

[0070] Electronic analytical balance: Germany Sartorius BT25s and BS124s

[0071] Ultrasonic cleaning machine: Beijing Ultrasonic Instrument Co., Ltd.

[0072] Chromatographic column: Agilent eclipse XDB C18 column (5μm, 4.6mm×250mm);

[0073] Reagents: Acetonitrile is chromatographically pure, water is ultrapure water; other reagents are analytically pure.

[0074] Reagent: Jichuanjian Granules (batch number: 1602001J).

[0075] (1) Chromatographic conditions

[0076] Use octadecylsilane bonded silica gel as filler (column length 250mm, inner diameter 4.6mm, particle size 5μm); use acetonitrile as mobile phase A, 0.1% phosphoric acid solution as mobile phase B, and carry out as specified in the following table Gradient elution. The flow rate is 1.0ml per minute; the column temperature is 30°C...

Embodiment 3

[0110] Example 3. Determination of Echinacoside, Ferulic Acid, Isoferulic Acid, and Neohesperidin Contents in the Jichuan Decoction Composition by High Performance Liquid Chromatography

[0111] Instruments and materials

[0112] (1) Main instrument Agilent1100 high performance liquid chromatography: diode array detector, quaternary low-pressure gradient pump, vacuum degasser, column thermostat, automatic sampler; data processor: Agilent1100 chromatography workstation; ten-thousandth electronic Analytical balance (BS 110S, Sartorius, USA); 1 / 100,000 electronic analytical balance (BP 211D, Sartorius, USA); ultrasonic cleaner.

[0113] (2) Experimental materials

[0114] Reagents: analytical grade methanol (Beijing Chemical Plant); chromatographic grade acetonitrile (Tianjin Biaoshiqi Technology Development Co., Ltd.); self-made redistilled water (Robust pure water obtained by distillation in an automatic double pure water still).

[0115] Chromatographic column: Agilent Eclip...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
lengthaaaaaaaaaa
particle diameteraaaaaaaaaa
correlation coefficientaaaaaaaaaa
Login to View More

Abstract

The invention discloses a quality control method of a Jichuan decoction composition, belonging to the field of traditional Chinese medicine analysis. The method of the present invention comprises adopting high performance liquid chromatography to establish the fingerprint of the Jichuan decoction composition, and the chromatographic conditions are as follows: the chromatographic column adopts octadecylsilane bonded silica gel chromatographic column; the detection wavelength is 320nm; the flow rate: 0.9-1.1ml / min column Temperature: 25-35°C; the number of theoretical plates calculated according to the peak of ferulic acid is not less than 5000; using acetonitrile (A)-0.1% phosphoric acid solution (B) as the mobile phase, gradient elution is carried out in the following order; the fingerprint of the present invention The map fully reflects the quality information of the Jichuan decoction composition, so that the purpose of more comprehensive and effective control of the product quality of the Jichuan decoction composition can be achieved.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine analysis, and relates to a quality standard detection method for traditional Chinese medicine compound granules. Background technique [0002] Traditional Chinese medicine decoction is the mainstream of clinical medicine, but because of decoction and inconvenient to carry, the quality of the decoction prepared by decoction often varies greatly depending on the person and the decoction utensils. The use of modern science and technology to develop traditional Chinese medicine preparations that are easy to carry and easy to take is not only the inheritance of traditional Chinese medicine, but also a better promotion of classic famous prescriptions. Clinical application. The preparation process of granules is relatively simple, easy to shape, easy to take and carry, and the form of taking is most consistent with traditional decoctions, and can maintain the characteristics of traditional de...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 林丽娜郭小芳刘志刚陈周全谭沛马鹏岗曾祥腾高云佳屠鹏飞
Owner CHINA RESOURCES SANJIU MEDICAL & PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com