Antitumor traditional Chinese medicine composition and applications thereof

A composition and anti-tumor technology, applied in the directions of anti-tumor drugs, drug combinations, medical preparations containing active ingredients, etc., to achieve the effects of fewer medicinal flavors, readily available raw materials, and abundant raw materials

Active Publication Date: 2018-08-28
YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] However, the theory of TCM is extensive and profound, there are many ways to combine TCM prescriptions, and the compatibility relationship between medicinal...

Method used

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  • Antitumor traditional Chinese medicine composition and applications thereof

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Embodiment 1

[0032] The preparation of embodiment 1 Chinese medicine composition of the present invention (one)

[0033] The weight ratio of each raw material medicine is: 9 parts of Sanleng, 9 parts of Curcuma, 15 parts of Pinellia, 15 parts of Radix Astragali, 15 parts of Radix Astragali, and 15 parts of Atractylodes Rhizoma. The preparation steps are as follows:

[0034] a) Extraction of traditional Chinese medicine: Take Sanleng, Curcuma Rhizoma and Atractylodes Rhizoma Atractylodes Rhizome, put them in an extraction container after proper crushing, add distilled water of 6 times the weight of the three medicinal materials, use steam distillation to reflux extraction for 8 hours, and collect volatile oil; put the crushed astragalus , Zhi Tian Nan Xing, and Zhi Pin Xia are added to the extraction container, and then distilled water of 6 times the total weight of the three medicinal materials is added, stirred evenly, decocted 3 times, and the amount of water added each time is 6 times t...

Embodiment 2

[0037] The preparation of embodiment 2 Chinese medicine composition of the present invention (two)

[0038] The weight ratio of each raw material medicine is: 9 parts of Sanleng, 9 parts of Curcuma, 20 parts of Pinellia, 20 parts of Araceae, 15 parts of Radix Astragali, and 15 parts of Atractylodes Rhizoma. The preparation steps are as follows:

[0039] a) Extraction of traditional Chinese medicine: take Sanleng, Zedoary and Atractylodes Rhizoma Rhizoma, put them in an extraction container after proper crushing, add distilled water of 10 times the weight of the three medicinal materials, use steam distillation to reflux extraction for 4 hours, and collect volatile oil; put the crushed Astragalus membranaceus , Zhi Tian Nan Xing, and Zhi Pin Xia are added to the extraction container, and then distilled water of 10 times the total weight of the three medicinal materials is added, stirred evenly, decocted twice, and the amount of water added each time is 10 times the total weight...

Embodiment 3

[0042] The preparation of embodiment 3 Chinese medicine composition of the present invention (three)

[0043] The weight ratio of each raw material is as follows: 9 parts of Sanleng, 9 parts of Curcuma, 15 parts of Pinellia, 15 parts of Radix Astragali, 30 parts of Astragalus, and 30 parts of Atractylodes Rhizoma. The preparation steps are as follows:

[0044] a) Extraction of traditional Chinese medicine: take Sanleng, Zedoary and Atractylodes Rhizoma Rhizome, put them in an extraction container after proper crushing, add distilled water of 8 times the weight of the three medicinal materials, use steam distillation to reflux extraction for 5 hours, and collect volatile oil; put the crushed astragalus , Zhi Tian Nan Xing, and Zhi Pin Xia are added to the extraction container, then add distilled water in an amount 8 times the total weight of the three medicinal materials, stir evenly, and decoct twice, each time the amount of water added is 8 times the total weight of the medic...

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Abstract

The invention relates to an antitumor traditional Chinese medicine composition and applications thereof, wherein the traditional Chinese medicine composition is prepared from the following bulk drugsby weight: 9-15 parts of Rhizoma Sparganii, 9-15 parts of Curcuma zedoaria, 15-20 parts of processed Pinellia ternata, 15-20 parts of processed Arisaema heterophyllum Blume, 15-30 parts of Milkvetch Root, and 15-30 parts of Atractylodes macrocephala. According to the present invention, the traditional Chinese medicine composition has effects of blood stasis removing, abdominal mass eliminating, phlegm removing, hard mass softening, body resistance supporting, spleen strengthening, qi benefiting and the like; the animal experiment results show that the traditional Chinese medicine composition can significantly inhibit the growth of MKN-45 gastric adenocarcinoma transplanted tumor in nude mice, down-regulate the PCNA expression and the EGFR expression in the gastric cancer tissue of nude mice, change the tumor microenvironment of walker-256 ascites model rats, and provide good treatment effects on tumors; and the traditional Chinese medicine composition has advantages of less variety ofbulk drugs, easy preparation, abundant and easily available raw materials and low cost.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to an anti-tumor traditional Chinese medicine composition and its application. Background technique [0002] Malignant tumor, also known as cancer, has become a common and frequently-occurring disease that threatens human life, and is the first of the top ten causes of death in urban population in my country. According to the report of the World Health Organization (WHO), the incidence of cancer in the world is increasing at a rate of 3% per year, and the number of deaths due to cancer is as high as more than 6 million people every year. Therefore, strengthening the research on the treatment of malignant tumors, improving the therapeutic effects of various existing methods, exploring new treatment approaches, improving the quality of life of cancer patients, reducing the recurrence rate, and reducing mortality are the urgent tasks of current clinical oncologists. [000...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P35/00
CPCA61K36/284A61K36/481A61K36/8884A61K36/8888A61K36/902A61K36/9066A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 郭晓冬韩克起朱全刚张院辉周小翠林丹
Owner YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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