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Method for increasing purity of extracted hesperidin and hesperidin

A technology of hesperidin and purity, which is applied in the field of hesperidin to improve the purity of hesperidin extraction, which can solve the problems of difficult purification, loss of hesperidin, high impurity content, etc., and achieve the effect of improving the purity

Inactive Publication Date: 2018-07-20
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when extracting hesperidin from plants such as sweet oranges and lemons, each extraction contains a large amount of impurities, and obtaining hesperidin with higher purity requires multiple purifications, which will inevitably cause orange depletion of peridin, thereby reducing the extraction rate of hesperidin
Especially the first extraction of Fructus Aurantii Fructus is black, indicating that the impurity content is extremely high and it is not easy to purify

Method used

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  • Method for increasing purity of extracted hesperidin and hesperidin
  • Method for increasing purity of extracted hesperidin and hesperidin
  • Method for increasing purity of extracted hesperidin and hesperidin

Examples

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Effect test

Embodiment 1

[0042] This embodiment provides a method for improving the purity of hesperidin extraction, comprising the following steps:

[0043] S1, remove impurities;

[0044] Take 100g Fructus Fructus Aurantii, pulverize Fructus Fructus Fructus Fructus Fructus Fructus Aurantii, after crushing Fructus Fructus Fructus Fructus Fructus Aurantii, pass 100 mesh sieves to obtain Fructus Fructus Fructus Fructus Aurantii coarse powder. Mix the coarse powder of Fructus Citrus Fructus with 100g of water to obtain the first mixture, and seal and soak it with a plastic wrap for 10 hours.

[0045] The first mixture was mixed with the sodium hydroxide solution, so that the pH of the mixture of the first mixture and the sodium hydroxide solution was 8, and the concentration of the sodium hydroxide solution was 0.12 mol / L.

[0046] The soaking time is 1 hour. After the soaking is completed, filter to remove the filtered mother liquor and collect the filtered residue.

[0047] S2, initial extraction; ...

Embodiment 2-3

[0056] Embodiment 2-3 provides a method for improving the purity of hesperidin extraction, and the basic operation of embodiment 2-4 is the same as that of embodiment 1, the difference is that the operating conditions change.

Embodiment 2

[0058] S1, remove impurities;

[0059] Fructus Fructus Aurantii is pulverized and passed through an 80-mesh sieve, mixed with water, the water is 120g, and the soaking time is 8 hours. The alkaline substance used is potassium hydroxide, the concentration is 0.12mol / L, and the pH value is 8.5. After adjusting the pH value, soak for 1.2 hours.

[0060] S2, initial extraction;

[0061] The lye used is potassium hydroxide, the concentration is 1mol / L, the pH value is 12, the soaking time is 2.5 hours, the concentrated hydrochloric acid is used to adjust the pH value to 3.5, and the standing time of the first extraction filtrate is 12 hours. The centrifugation speed is 4000r / min, and the centrifugation time is 10 minutes.

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Abstract

The invention relates to the field of drug extraction, in particular to a method for increasing the purity of extracted hesperidin and the hesperidin. The method for increasing the purity of the extracted hesperidin includes the following steps that an alkaline substance is adopted to adjust the pH value of aurantii fructus immaturus coarse powder to 8-9, then, the aurantii fructus immaturus coarse powder is soaked for 1-2 hours, then, filtration is carried out to remove mother liquor, and residues obtained through filtration are extracted to obtain the hesperidin. According to the method forincreasing the purity of the extracted hesperidin, by adding the alkaline substance into the aurantii fructus immaturus coarse powder, impurities in aurantii fructus immaturus extract can be largely removed, the purity of the hesperidin is increased, but the extraction efficiency of the hesperidin cannot be influenced. The method for increasing the purity of the extracted hesperidin can be appliedto industrial production in a large scale.

Description

technical field [0001] The invention relates to the field of medicine extraction, in particular to a method for improving the purity of hesperidin extracted and hesperidin. Background technique [0002] Hesperidin, also known as nobiletin and dihydroflavone glycosides, is the extract of sweet orange and lemon, which can be used as vitamin P drugs to enhance the toughness of capillaries. The extraction of hesperidin generally involves multiple extractions of Citrus aurantium, and after extraction, the extracts of each extraction are mixed, and then purified to obtain the final hesperidin. However, when extracting hesperidin from plants such as sweet orange and lemon, each extraction contains a large amount of impurities, and obtaining hesperidin with higher purity requires multiple purifications, which will inevitably cause orange The loss of peridin, and then reduce the extraction rate of hesperidin. Especially the extract obtained from the first extraction of Fructus Aura...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H1/08C07H17/07
CPCC07H1/08C07H17/07
Inventor 李竣王德彬白蒙蒙杨光忠黄先菊张兴锋
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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