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Application of astragalus membranaceus flavonoid extract to preparation of medicines for treating leukopenia

A technology of leukopenia and astragalus flavonoids, which is applied in the field of application of astragalus flavone extracts in the preparation of drugs for the treatment of leukopenia, can solve the effect of increasing white blood cells, has not been seen, and has no leukopenia-related effects of astragalus flavonoids Reporting and other issues, to achieve the effect of low cost and simple extraction process

Inactive Publication Date: 2018-06-15
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, although Radix Astragali and Radix Astragali Injection have the effect of increasing leukocytes, their active ingredients are still unclear, and their medicinal effects are limited, and there are no reports on the effects of Astragalus flavonoids and their extracts on leukopenia. The extract composed of the above active ingredients has no report on the treatment of leukopenia

Method used

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  • Application of astragalus membranaceus flavonoid extract to preparation of medicines for treating leukopenia
  • Application of astragalus membranaceus flavonoid extract to preparation of medicines for treating leukopenia
  • Application of astragalus membranaceus flavonoid extract to preparation of medicines for treating leukopenia

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Embodiment 1

[0016] The preparation of embodiment 1 Astragalus flavonoids extract

[0017] Take 1000g of Radix Astragali, crush it, add 8L of water, heat and reflux for extraction 3 times, each time for 1 hour, combine the obtained extracts, concentrate under reduced pressure to obtain a paste. Separate the above paste with AB-8 macroporous adsorption resin column, elute with water, 10%, and 35% ethanol in sequence, collect the 35% ethanol eluate, concentrate and dry under reduced pressure, and concentrate the above 35% ethanol eluate The product was dispersed in 200 mL of water, extracted twice with 1 volume of ethyl acetate, the extracts were combined, concentrated under reduced pressure to obtain extract, and dried in vacuum at 60°C to obtain 1125 mg of astragalus flavonoids extract.

Embodiment 2

[0018] The preparation of embodiment 2 astragalus flavonoids extract

[0019] Take 1000 g of Radix Astragali, add 8 L of 20% ethanol, heat and reflux for extraction twice, each time for 2 hours, combine the obtained extracts, concentrate under reduced pressure to obtain a paste. Separate the above paste with AB-8 macroporous adsorption resin column, elute with water, 10%, and 35% ethanol in sequence, collect the 35% ethanol eluate, concentrate and dry under reduced pressure, and concentrate the above 35% ethanol eluate The product was dispersed in 200mL water, extracted once with 2 times the volume of ethyl acetate, the extracts were combined, concentrated under reduced pressure to obtain an extract, and dried in vacuo at 60°C to obtain 943 mg of astragalus flavonoids extract.

Embodiment 3

[0020] The preparation of embodiment 3 astragalus flavonoids extract

[0021] Take 1000 g of Radix Astragali, add 8 L of 95% ethanol, heat and reflux for extraction twice, each time for 1 hour, combine the obtained extracts, concentrate under reduced pressure to obtain a paste. Separate the above paste with AB-8 macroporous adsorption resin column, elute with water, 10%, and 35% ethanol in sequence, collect the 35% ethanol eluate, concentrate and dry under reduced pressure, and concentrate the above 35% ethanol eluate The product was dispersed in 200mL of water, extracted twice with 2 times the volume of ethyl acetate, the extracts were combined, concentrated under reduced pressure to obtain an extract, and dried in vacuo at 60°C to obtain 1064 mg of astragalus flavonoids extract.

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Abstract

The invention provides the application of an astragalus membranaceus flavonoid extract to preparation of medicines for treating leukopenia. The astragalus membranaceus flavonoid extract has the flavonoid content of 40-60%, and comprises the following main chemical components: formononetin, ononin, calycosin, calycosin-7-O-beta-D-glucopyranose, 7, 2'-dihydroxy-3', 4'-dimethoxyisoflavane, 2'-hydroxy-3', 4'-dimethoxyisoflavan-7-O-beta-D-glucopyranose, 3-hydroxy-9, 10-dimethoxypterocarpane and 9,10-dimethoxypterocarpane-3-O-beta-D-glucopyranose. The astragalus membranaceus flavonoid extract has arelatively good effect of increasing leukocytes and can be applied to preparation of the medicines for treating or preventing the leukopenia or auxiliary chemoradiotherapeutic medicines.

Description

technical field [0001] The invention relates to a new application of the astragalus flavone extract, in particular to the application of the astragalus flavone extract in preparing medicines for treating or preventing leukopenia. Background technique [0002] Leukopenia refers to the number of white blood cells in peripheral blood below 4.0×10 9 / L. A decrease in the number of white blood cells will weaken the body's immunity, and severe infection and bleeding often occur clinically. There are many causes of leukopenia, such as hemorrhage, tumor radiotherapy and chemotherapy, bacterial virus infection, etc., but most of them are leukopenia caused by radiotherapy and chemotherapy. [0003] White blood cell-increasing drugs (abbreviated as leucocyte-increasing drugs) are a class of drugs that can increase the number of white blood cells in the body and effectively treat leukopenia. Clinically used Baiyao mainly includes three categories: western medicine, biological product...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61P7/00
CPCA61K36/481A61K2236/333A61K2236/35A61K2236/39A61K2236/51A61K2236/55
Inventor 李震宇王二兵曲婷丽秦雪梅
Owner SHANXI UNIV
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