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Monodisperse superparamagnetic nano-magnetic beads and their applications in the detection of benzodiazepines*

A superparamagnetic and nano-magnetic bead technology, applied in the direction of magnetic objects, organic materials/organic magnetic materials, magnetic materials, etc., can solve the problems of large operator influence, cumbersome and time-consuming steps, poor reliability, etc. Achieve the effect of less manual intervention and simplified steps

Active Publication Date: 2019-08-02
SHANGHAI CRIMINAL SCI TECH RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention is aimed at existing detection benzodiazepine Drug-like methods generally have the defects of cumbersome and time-consuming steps, large consumption of reagents, great influence by operators, or poor reliability. A monodisperse superparamagnetic nano-magnetic bead and its benzodiazepine For the detection application of similar drugs, the sulfonate-stabilized monodisperse superparamagnetic nano-ferric oxide ferric oxide was prepared by an improved hydrothermal synthesis method, and the ε-caprolactam group and phenyl structure were modified after silane modification. Using these two structures Synergistic, selective removal of benzodiazepines from biological samples drug-like adsorption; the present invention utilizes functionalized nano-magnetic beads and benzodiazepine The advantages of selective enrichment and separation of drug-like drugs can significantly improve the efficiency of pretreatment, reduce the influence of human factors, and greatly improve the accuracy of detection. Accurate testing of similar drugs provides a more reliable guarantee

Method used

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  • Monodisperse superparamagnetic nano-magnetic beads and their applications in the detection of benzodiazepines*
  • Monodisperse superparamagnetic nano-magnetic beads and their applications in the detection of benzodiazepines*
  • Monodisperse superparamagnetic nano-magnetic beads and their applications in the detection of benzodiazepines*

Examples

Experimental program
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Embodiment 1

[0023] The present embodiment specifically comprises the following steps: dissolving 0.65g of anhydrous ferric chloride into 30mL of dipropylene glycol and 30mL of ethylene glycol mixture, adding 0.35g of sodium polystyrene sulfonate, and stirring for 1 hour until uniform , and then add 3.5g of sodium acetate, stir for 1 hour until uniform, then pour the above mixed solution into a polytetrafluoroethylene reactor, and put it into an oven at 200 ° C for 8 hours. After being cooled to room temperature, it was cleaned with deionization, and dried at 60° C. to obtain 100 nm monodisperse superparamagnetic ferric oxide nanospheres (Fe 3 o 4 ).

Embodiment 2

[0025] This embodiment specifically includes the following steps: dissolve 2 g of anhydrous ferric chloride into 110 mL of ethylene glycol, add 1.5 g of sodium polystyrene sulfonate, stir for 1 hour until uniform, then add 8 g of sodium acetate, and stir for 1 hour until uniform, then pour the above mixed solution into a polytetrafluoroethylene reactor, put it into an oven and react at 200°C for 10 hours. After being cooled to room temperature, it was cleaned with deionization, and dried at 60° C. to obtain 500 nm monodisperse superparamagnetic ferric oxide nanospheres (Fe 3 o 4 ).

Embodiment 3

[0027] This embodiment specifically includes the following steps: disperse 2 g of the 500 nm monodisperse superparamagnetic ferric iron tetroxide nanospheres prepared in Example 2 in 350 mL of isopropanol and 100 mL of deionized water, ultrasonically disperse for 30 minutes, and add 6 g of tetra-orthosilicate Ethyl ester, 2g of γ-methacryloxypropyltrimethoxysilane and 1mL of acetic acid, mechanically stirred and heated to 60°C, reacted for 6 hours, cooled to room temperature, cleaned with deionized and ethanol, 60°C Under drying, the vinyl modified monodisperse superparamagnetic ferric oxide nanospheres (Fe 3 o 4 @vinyl).

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Abstract

The invention discloses a monodisperse superparamagnetic nano magnetic bead and detection application of benzodiazepine * drugs thereof. The nano magnetic beads are applied to detecting the benzodiazepine * drugs. The method specifically comprises the following steps: dissolving a to-be-detected body fluid into an aqueous solution of ammonia, adding the monodisperse superparamagnetic nano magneticbeads, performing adsorption and elution, and detecting the content of the benzodiazepine * drugs by virtue of liquid chromatography mass spectrometry. By utilizing the selective enrichment and separation advantages of functional nano magnetic beads and benzodiazepine * drugs, the pretreatment efficiency can be obviously improved, influences of human factors are reduced, the detection accuracy isgreatly improved, and a reliable guarantee is provided for accurate detection of trace benzodiazepine * drugs.

Description

technical field [0001] The present invention relates to a technology in the field of chemical detection, in particular to a magnetic solid-phase extraction automation technology for detecting benzodiazepines drug-like approach. Background technique [0002] Benzodiazepine These drugs have the characteristics of less dosage, fast metabolism, and short half-life, and their concentrations in tissues and body fluids in the body are very low, and most of them are transformed into metabolites and are quickly excreted with urine. It is the urine, saliva or blood of the subject several hours or even tens of hours after taking the medicine, so benzodiazepines The content of similar drugs and their metabolites is relatively low, and a highly sensitive detection method is required. Contents of the invention [0003] The present invention is aimed at existing detection benzodiazepine Drug-like methods generally have the defects of cumbersome and time-consuming steps, large con...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01F1/00H01F1/42C01G49/08B82Y30/00B82Y40/00G01N30/02G01N30/06
CPCB82Y30/00B82Y40/00C01G49/08C01P2004/32C01P2004/62C01P2004/64G01N30/02G01N30/06H01F1/0054H01F1/42
Inventor 杨飞宇倪春芳汪蓉梁晨张玉荣孙奋进邹芸袁晓亮曹芳琦刘文斌
Owner SHANGHAI CRIMINAL SCI TECH RES INST
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