Use of Echinacea and Salvia miltiorrhiza extracts for preparing antiviral composition and preparation method of antiviral composition

An extract, echinacea technology, applied in the direction of antiviral agents, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve children's severe burden, worry about complications, lack of enterovirus type 71 and human adenovirus. Specific antiviral drugs and other issues to achieve the effect of inhibiting adenovirus and enterovirus infection and reducing drug resistance

Active Publication Date: 2021-08-10
张銮英
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Thus, adenovirus infection leads to severe disease burden and worrisome complications in children
[0004] Currently there is a lack of specific antiviral drugs for the treatment of enterovirus 71 and human adenovirus

Method used

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  • Use of Echinacea and Salvia miltiorrhiza extracts for preparing antiviral composition and preparation method of antiviral composition
  • Use of Echinacea and Salvia miltiorrhiza extracts for preparing antiviral composition and preparation method of antiviral composition
  • Use of Echinacea and Salvia miltiorrhiza extracts for preparing antiviral composition and preparation method of antiviral composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Analysis of Preparation and Index Components of Plant Extract

[0066] 1.1 preparation method

[0067] This example is an example of the preparation method of a plant extract of the present invention for preparing an antiviral composition. Purple cone extracts and salviases are extracted with water or alcohol water mixtures. The alcohol water mixture is a mixture of various alcohols and water, such as aqueous solution of methanol, an aqueous ethanol, 2-propanol, wherein the alcohol is a volume ratio (V / V) of the alcohol water mixture. 1 ~ 95%. The extracts of different kinds of plants have a similar method, and below the water extract of water taps and the 70% ethanol extract of the salvia miltiorrhiza, the preparation of the water extract or alcohol extract of the two plants will be described.

[0068] To prepare a water extract of purple cone, the upper or roots of the purple cone flowers are first dried at 45 to 50 ° C to a water content of about 8 to 12%, and pulveriz...

Embodiment 2

[0084] Anti-viral activity of purple cone flower extracts and salviae extract

[0085] In this embodiment, the human adenovirus 3 and the bowel virus 71 are illustrative, and the utility model of the purple cone flower extract and the salviae extract against the adenovirus and the bowel virus are described. By viral gotten spot test, the researchers screened from hundreds of plant extracts to the human adenovirus 3 and bowel virus 71-optimum antiviral activity plant extracts are water cone flowers and salviae extracts. .

[0086] Figures 3A-3B The water extract (EPA-W) on the upper portion of the petilic cone flower of the present invention is displayed, respectively, the antiviral effect of human adenovirus 3 and bowel virus 71; Figure 3C-3D The 70% ethanol extract (referred to as SMF-2-E) of the inventive dandeng root portion and the root portion, respectively, to antiviral effects of human adenovirus 3 and bowel virus 71. against Figures 3A-3D The dose reaction curve conducts ...

Embodiment 3

[0092] Anti-viral activity of hydrolyzing with purple cone flowers and salviases of ethanol extract

[0093] This embodiment further analyzes the hydrolysis activity of the water extract of the water extract of the purple cappolic flow of the present invention and the ethanol extract of the sterilin in different proportion of anti-viral activity. Table 6 shows a different proportion of hydrolysis (EPA-W) on the upper portion of the solar cone flower and 70% ethanol extract (referred to as SMF-2-E) of the root of the stem against the human adenovirus 3 type and intestines Virus 71 effect. Based on Table 6, the compositions of EPA-W and SMF-2-E ratios 1: 9 to 9: 1 have a relatively low IC50 of anti-human adenovirus 3 and anti-intestinal virus 71 type. IC90. When EPA-W is mixed with SMF-2-E by weight than 3: 7, the resulting composition on the human adenovirus 3 and bowel virus 71 type antiviral effects are respectively Figure 4A and Figure 4b Indicated. The composition has the lowes...

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Abstract

The present invention provides an application of a plant extract for preparing an antiviral composition. The plant extract comprises an extract of Echinacea flower, an extract of Salvia miltiorrhiza, or a combination thereof, which can kill adenovirus, inhibit adenovirus Adsorb with enterovirus and penetrate cells to prevent adenovirus and enterovirus infection. The invention also provides a preparation method of antiviral composition against adenovirus and enterovirus.

Description

Technical field [0001] The present invention relates to a plant extract for the preparation of an antiviral composition and a method of preparation of the antiviral composition, particularly with respect to water cone flowers and salvia miltate extracts for the preparation of antiviral compositions and contains purple. Method for preparing cone flowers and salviae extracts. Background technique [0002] Since 1969 Intestinal Virus 71 (ENTEROVIRUS 71, also referred to as EV71) was initially discovered in California, USA, which was considered to be related to the United States, Europe, Australia, Japan, Brazil, and Malaysia and other places. Prior to 1988, Bulgaria, Hungary, and Malaysia were in 1975, 1978, and in 1997, three serious outbreaks occurred, resulting in dozens of lethal cases. The most serious intestinal virus 71 epidemics in the last century were burst in Taiwan in China in 1998. The statistical report showed that there were 129,106 hand-foot-mouth disease (HERPANGINA...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61P31/20A61P31/14
CPCA61K36/28A61K36/537A61K2236/331A61K2236/333A61K2300/00
Inventor 张銮英陈裕星
Owner 张銮英
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