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Preparation method of compound clobetasol propionate ointment test solution

A technology of compound chlorine propionate and test solution, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve problems such as improper operation and errors of analysts, and achieve the effects of releasing help, reducing errors, and eliminating operating errors

Inactive Publication Date: 2018-05-18
JIANGSU SEMPOLL PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The invention provides a method for preparing the test solution of compound clobetasol propionate ointment to solve the problem of errors caused by improper operation of analysts in the process of preparing the test solution of compound clobetasol propionate ointment

Method used

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  • Preparation method of compound clobetasol propionate ointment test solution

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Embodiment Construction

[0011] In order to make the purpose, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0012] figure 1 It is a flowchart of the preparation method of the compound clobetasol propionate ointment test solution according to the embodiment of the present invention. Such as figure 1 As shown, the preparation method of compound clobetasol propionate ointment provided by the invention for testing solution may further comprise the steps:

[0013] In step S10, put the compound clobetasol propionate ointment sample of 2 g in the 100 ml brown volumetric flask, then add methanol solution;

[0014] In step S11, the volumetric flask was heated and oscillated in a water bath at 80° C., and the volumetric flask was heated and oscillated using a constant temperature water bath shaker. The time for heating and oscillating the volumetric fl...

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Abstract

The invention provides a preparation method of a compound clobetasol propionate ointment test solution. The preparation method comprises the following steps: adding 2g of a compound clobetasol propionate ointment sample into a 100ml brown volumetric flask; adding a methanol solution; putting the volumetric flask into a water bath with the temperature of 80 DEG C and heating and shaking, wherein the time for heating and the time for shaking are 10min respectively; cooling the heated volumetric flask in a dark place to room temperature; then adding methanol to the scale; uniformly shaking and filtering; taking subsequent filtrate as the test solution. According to the preparation method provided by the invention, the heating temperature, the heating time and the shaking time of the volumetric flask containing the compound clobetasol propionate ointment sample and the methanol solution are reasonably controlled, so that operation errors between analysts are effectively eliminated and therelease of clobetasol propionate and a vitamin A acid main drug is greatly helped.

Description

technical field [0001] The invention relates to a preparation method of a test solution, in particular to a preparation method of a compound clobetasol propionate ointment test solution. Background technique [0002] Compound clobetasol propionate ointment, commonly known as Jinnuer, is usually used to treat psoriasis vulgaris. Compound clobetasol propionate ointment is a compound preparation, its main components are 10 mg clobetasol propionate and 5 mg all-trans retinoic acid. Clobetasol propionate is a potent hormone, long-term use can cause side effects such as skin atrophy, and the side effect commonly used in the use of tretinoin is skin irritation. In addition, transdermal absorption of drugs into the blood circulation system will produce systemic toxic and side effects. Therefore the precision and the accuracy requirement to the mensuration of compound clobetasol propionate ointment content are very high. The preparation of compound clobetasol propionate ointment t...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 付劼戴菊英王晶
Owner JIANGSU SEMPOLL PHARMA
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