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Composition for alleviating skin inflammation caused by yellow dust and fine particulate, comprising natural plant extract

A technology for skin inflammation and fine particulate matter, applied in the field of compositions for skin inflammation

Inactive Publication Date: 2018-05-11
CELLTRION INC +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Therefore, the present inventors have confirmed that acid orange peel extract, Shade fern extract and chestnut parasitic extract reduce skin inflammation caused by yellow dust and fine particles, thereby completing the present invention

Method used

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  • Composition for alleviating skin inflammation caused by yellow dust and fine particulate, comprising natural plant extract
  • Composition for alleviating skin inflammation caused by yellow dust and fine particulate, comprising natural plant extract
  • Composition for alleviating skin inflammation caused by yellow dust and fine particulate, comprising natural plant extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Embodiment 1. The preparation of sour orange peel, yin terrestrial fern and chestnut parasite extract

[0078] 500ml of 70% ethanol (purified water and ethanol are mixed in a volume ratio of 30:70) were added to 50g of dried and pulverized sour orange peel, sage fern or chestnut parasite, and then the resulting mixture was shaken at room temperature for 20 hours, to obtain the extract. These extracts were filtered and concentrated under reduced pressure to remove ethanol therefrom, and the resulting concentrates were freeze-dried to obtain ethanol extracts of tangerine peel, fern fern and chestnut parasitic in yields of 17.9%, 18.3% and 15%, respectively.

Embodiment 2

[0079] Embodiment 2. the preparation of yellow dust and fine particulate matter extract

[0080] (1) Collection of yellow dust and fine particles

[0081] Using a Low Volume Air Sampler (Low Volume Air Sampler) installed in Bucheon, Gyeonggi-do in March 2013, the collected air was collected for 24 hours at a flow rate of 16.7 L / min using a sampler (Sampler) equipped with a 47 mm Teflon filter. sample. According to the filter type, samples of yellow dust, TSP, PM10 and PM2.5 were collected respectively.

[0082] (2) Preparation of yellow dust and fine particle extract

[0083] Distilled water, ethanol and chloroform were added to cut about 1m 2 size filter, and then the resulting filtrate was stirred for 12 hours to obtain the extract. The resulting extract was separated, and then the extraction solvent was added again to the extraction residue, and the extract was obtained again by ultrasonication for 4 hours. The extracts were combined together and concentrated under...

experiment example 1

[0084] Experimental Example 1. Evaluation of Inflammation-Inducing Ability of Yellow Dust and Fine Particle Extracts

[0085] The following experiments were performed to confirm whether the extracts of yellow dust, TSP, PM10 and PM2.5 caused inflammation in the cells.

[0086] (1) Evaluation of NO generation caused by

[0087] NO is a pro-inflammatory mediator that is produced by various inflammatory stimuli, and it is known to elicit a sustained inflammatory response and lead to tissue damage. Therefore, it was confirmed whether the yellow dust and fine particulate matter extracts lead to the production of NO. Raw 264.7 cells were divided into 6×10 4 cells / well were seeded into a 96-well plate (Well Plate), and then the resulting cells were incubated at 37°C and 5% CO 2 conditions for 24 hours. The resulting cells were treated with samples of yellow dust, TSP, PM10 or PM2.5 diluted at various concentrations, and the resulting treated cells were cultured for another 24 h...

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Abstract

The present invention relates to a composition for alleviating inflammation caused by yellow dust and fine particulate, comprising a natural plant extract. The plant extract of the present invention inhibits NO generation, and inflammatory cytokine production, caused by yellow dust and fine particulate, and thus has an excellent effect of preventing or improving skin inflammation caused by yellowdust, fine particulate, and the other harmful materials.

Description

technical field [0001] The present invention relates to a composition for alleviating skin inflammation caused by yellow dust and fine particles, and more particularly to a composition for alleviating skin inflammation caused by harmful atmospheric environment, comprising natural plant extracts, It contains, as an active ingredient, one or more extracts selected from the group consisting of sour orange peel extract, shady fern extract and chestnut extract. Background technique [0002] When damage is caused by physical stimulation, chemical substances, bacteria, etc., the inflammatory response (Inflammatory Response) of the skin begins to appear as an activity to protect the skin against damage. In response, Keratinocytes or Langerhans cells emit different types of cytokines that cause this inflammatory response. Interleukin-8 (Interleukin-8; IL-8), Interleukin-6 (Interleukin-6; IL-6), Interleukin-1 (Interleukin-1; IL-1), tumor necrosis factor-α (Tumor Necrosis Factor-α; T...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/9749A23L33/105A61K36/12A61K36/185A61K36/752A61Q19/00
CPCA61Q19/00A61K36/12A61K36/185A23L33/105A61K9/0014A61K9/107A61K8/9794A61K36/752A61K8/9749A61K8/9789A61P17/00A61K8/9741A61K2300/00A61K8/06A61K2800/5922A61Q17/00
Inventor 金在勋李胜基任周爀金衍叔文源刚崔致镐尹光埈文诚浩李圣铉廉明勋安秀美金京昱成美京张永杓金珍珠
Owner CELLTRION INC
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