Shell-core alpha-totaxin microcapsule and preparation method thereof
A technology of tocopherol and microcapsules, which is applied in the direction of microcapsules, capsule delivery, pharmaceutical formulations, etc. It can solve the problems that affect the quality of microcapsule products, cannot be used for production and processing, and controllable core material content and particle size are difficult to achieve.
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Embodiment 1
[0023] Prepare shell core α-tocopherol microcapsules by microfluidics: Take 10 g α-tocopherol and dissolve it in 30 g diluent (benzyl benzoate: white oil = 2:1), draw it with a syringe as F inner , use a syringe to draw sodium alginate and white oil solutions as F middle and F outer . Adjust F inner and F middle The flow rates were 4 and 40 μL / min, F outer The flow rate is 2000μL / min, forming single-core microcapsules and falling into CaCL 2 In the solution, gel microspheres with a core-shell structure are formed, washed with deionized water after 1-2 hours, and then dried naturally.
Embodiment 2
[0025] Prepare shell core α-tocopherol microcapsules by microfluidics: Take 10 g α-tocopherol and dissolve it in 30 g diluent (benzyl benzoate: white oil = 2:1), draw it with a syringe as F inner , use a syringe to draw sodium alginate and white oil solutions as F middle and F outer . Adjust F inner and F middle The flow rates were 4 and 40 μL / min, F outer The flow rate is 1500μL / min, forming dual-core microcapsules and falling into CaCL 2 In the solution, gel microspheres with a core-shell structure are formed, washed with deionized water after 1-2 hours, and then dried naturally.
Embodiment 3
[0027] Prepare shell core α-tocopherol microcapsules by microfluidics: Take 10 g α-tocopherol and dissolve it in 30 g diluent (benzyl benzoate: white oil = 2:1), draw it with a syringe as F inner , use a syringe to draw sodium alginate and white oil solutions as F middle and F outer . Adjust F inner and F middle The flow rates were 4 and 40 μL / min, F outer The flow rate is 800μL / min, forming three-core microcapsules and falling into CaCL 2 In the solution, gel microspheres with a core-shell structure are formed, washed with deionized water after 1-2 hours, and then dried naturally.
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