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Shell-core alpha-totaxin microcapsule and preparation method thereof

A technology of tocopherol and microcapsules, which is applied in the direction of microcapsules, capsule delivery, pharmaceutical formulations, etc. It can solve the problems that affect the quality of microcapsule products, cannot be used for production and processing, and controllable core material content and particle size are difficult to achieve.

Inactive Publication Date: 2018-04-06
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation of microcapsules by spray drying method must be treated with high temperature hot air, which will lead to the oxidation of α-tocopherol, and the spray drying method is difficult to achieve in terms of controllable core material content and uniform particle size, thus affecting the quality of microcapsule products ; The used curing agents such as formaldehyde and glutaraldehyde in the complex coagulation method are all chemical substances and cannot be used in the production and processing of the food industry
Most of the existing microencapsulation methods are difficult to achieve uniform particle size and controllable core material content, resulting in uncontrollable release during use, which cannot meet the ideal requirements

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Prepare shell core α-tocopherol microcapsules by microfluidics: Take 10 g α-tocopherol and dissolve it in 30 g diluent (benzyl benzoate: white oil = 2:1), draw it with a syringe as F inner , use a syringe to draw sodium alginate and white oil solutions as F middle and F outer . Adjust F inner and F middle The flow rates were 4 and 40 μL / min, F outer The flow rate is 2000μL / min, forming single-core microcapsules and falling into CaCL 2 In the solution, gel microspheres with a core-shell structure are formed, washed with deionized water after 1-2 hours, and then dried naturally.

Embodiment 2

[0025] Prepare shell core α-tocopherol microcapsules by microfluidics: Take 10 g α-tocopherol and dissolve it in 30 g diluent (benzyl benzoate: white oil = 2:1), draw it with a syringe as F inner , use a syringe to draw sodium alginate and white oil solutions as F middle and F outer . Adjust F inner and F middle The flow rates were 4 and 40 μL / min, F outer The flow rate is 1500μL / min, forming dual-core microcapsules and falling into CaCL 2 In the solution, gel microspheres with a core-shell structure are formed, washed with deionized water after 1-2 hours, and then dried naturally.

Embodiment 3

[0027] Prepare shell core α-tocopherol microcapsules by microfluidics: Take 10 g α-tocopherol and dissolve it in 30 g diluent (benzyl benzoate: white oil = 2:1), draw it with a syringe as F inner , use a syringe to draw sodium alginate and white oil solutions as F middle and F outer . Adjust F inner and F middle The flow rates were 4 and 40 μL / min, F outer The flow rate is 800μL / min, forming three-core microcapsules and falling into CaCL 2 In the solution, gel microspheres with a core-shell structure are formed, washed with deionized water after 1-2 hours, and then dried naturally.

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Abstract

The invention discloses a shell-core alpha-totaxin microcapsule and a preparation method thereof. An O / W / O liquid drop template is prepared by adopting a microfluidics splitter through taking alpha-totaxin as a core material and adding a dilutent and taking sodium alginate as a wall material. The number of core materials wrapped by the microcapsules can be controlled by regulating the internal andexternal phase flow rate, and the spherical shape of a shell layer can be kept well by adopting curing means of combining internal and external gelatinization. The Finner and Fmiddle flow rate are constant, the Fouter flow rate is regulated so as to control the number of the core materials wrapped in the shell-core microcapsules, the alpha-totaxin microcapsule with uniform grain size and a shell-core structure, and the cured liquid drop can keep good sphere through combining the internal and external gelatinization.

Description

technical field [0001] The present invention relates to microcapsule technology, in particular to a kind of α-tocopherol microgel [0002] Capsules and methods of making them. Background technique [0003] Vitamin E belongs to a group of liquid-soluble vitamins whose chemical term is alpha-tocopherol. It has been shown to have potential health benefits such as anti-oxidation and free radical scavenging. However, its applications in food, drugs and cosmetics degrade rapidly in the presence of light and oxygen. Various encapsulation techniques have been developed to address these issues as they effectively separate the active ingredients from their surroundings. [0004] In recent years, microcapsule technology has developed rapidly, and spray drying and complex coacervation are widely used in actual production. The preparation of microcapsules by spray drying method must be treated with high temperature hot air, which will lead to the oxidation of α-tocopherol, and the sp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/36A61K47/06A61K47/14A61K47/26A61K47/02A61K31/355A61P39/06A61K8/67A61K8/11A61Q19/08A23L33/15
CPCA61K9/5036A23L33/15A23V2002/00A61K8/11A61K8/678A61K9/501A61K9/5015A61K31/355A61Q19/08A23V2250/712
Inventor 纪红兵黄丽云
Owner SUN YAT SEN UNIV
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