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Signal drift determination and correction

A signal and background signal technology, applied in the field of signal drift determination and correction, can solve the problems of unreliable two-color correction technology correction technology, background signal changes, and inaccuracy, so as to reduce idle time, reduce complexity, and relax precision the effect of the requirements

Active Publication Date: 2021-12-10
F HOFFMANN LA ROCHE & CO AG
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in some cases the background signal may change over time, e.g. after cuvette movement
This can lead to less reliable and / or less accurate two-color correction techniques and other correction techniques

Method used

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  • Signal drift determination and correction
  • Signal drift determination and correction
  • Signal drift determination and correction

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Embodiment Construction

[0027] Methods for determining background drift in an optical measurement signal and specific aspects of analyzers that include a background drift detection module are discussed below.

[0028] to combine Figure 1 to Figure 3 , some aspects of determining and correcting background drift in optical measurement signals will be discussed. Then, combine Figure 4 to Figure 6 , different aspects of an analyzer comprising a background drift detection module according to the invention will be dealt with in more detail.

[0029] Figure 1 to Figure 3 Shown is a method for determining background drift in an optical measurement signal of, for example, a sample analyzer, the method comprising obtaining the results of a plurality of sets of optical measurements 2a-2e, 4a-4f performed on a sample by, for example, an analyzer at different points in time, Each set of measurements 2a-2e, 4a-4f includes at least one measurement obtained in the first channel (e.g. at the first wavelength λ ...

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Abstract

One aspect of the invention relates to a method for determining background drift, the method comprising: acquiring a plurality of sets of optical measurements of a sample taken by a sample analyzer at different points in time, each set of optical measurements included in at least a first channel One measurement obtained and another measurement obtained in a second channel different from the first channel, the plurality of sets of optical measurements comprising a group and another group, the measurements in the one group showing The signal variation of the group is larger than the measurement result in the other group, based on the relationship of the measurement results in the first channel and the second channel in the one group, a first background signal is determined, based on the one group and the Describe the relationship between the measurement results in the first channel and the second channel in another group, determine the second background signal, and determine the background drift based on the first background signal and the second background signal.

Description

technical field [0001] The invention relates to a method for determining a background drift in an optical measurement signal and an analyzer comprising a background drift detection module. Background technique [0002] Various types of optical measurement methods are used in many automated sample analyzers. For example, a clinical chemistry analyzer can be configured to measure the absorbance of a biological sample based on such a measurement method to determine single or multiple parameters of the biological sample. Optical measurements can be affected by different types of background signals. One technique for reducing the effect of background signals is the so-called two-color correction technique. This technique may involve taking measurements at two different wavelengths and subtracting the two measurements to remove the constant background signal contained in the two measurement signals. However, in some cases the background signal may change over time, for example,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/01
CPCG01N21/01G01N21/253G01N21/272G01N21/274G01N21/82G01N35/00G01J3/28G01N21/03G01N35/00693G01N2201/127
Inventor R·诺伯尔
Owner F HOFFMANN LA ROCHE & CO AG
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