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Method for obtaining agitated depression animal model and application thereof

An animal model, a technology of depression, applied in the biological field, can solve problems such as not reflecting the characteristics of depression in animals

Inactive Publication Date: 2018-03-09
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently commonly used drug efficacy evaluation methods only reflect depression characteristics such as stress and despair, and the same commonly used anti-anxiety drug efficacy evaluation methods do not reflect the depression characteristics of animals

Method used

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  • Method for obtaining agitated depression animal model and application thereof
  • Method for obtaining agitated depression animal model and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0129] Example 1 Evaluation of the Drug Effect of Levo-Stepheridine (l-SPD) on Anxiety-induced Depression

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Abstract

The invention provides a method for obtaining an agitated depression animal model and application thereof, and particularly provides a method for obtaining the agitated depression animal model in a non-diagnostic and non-therapeutic mode. The agitated depression animal model obtained through the method not only shows depressive behaviors, but also shows anxiety behaviors. An agitated depression treatment effect can be evaluated more effectively through the model, and the method can further be used for screening therapeutic agents for treating agitated depression.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a method for obtaining an animal model of anxiety-induced depression and its application. Background technique [0002] Depression is a common mood disorder. In severe cases, suicidal thoughts and behaviors may occur. 16% of the population will be affected by it at some point in their lives. Depressive disorder is a serious mental disorder characterized by high prevalence, high relapse rate, high disability rate and high suicide rate. Depression not only seriously affects the physical and mental health of patients, but also brings a lot of economic burden. From the comprehensive analysis of clinical diagnosis, pathological mechanism and treatment outcome, depressive disorder is a kind of extremely complex mental illness. [0003] An important reason for the difficulty in treating depression is the complexity of the depressive disorder. Since depressive disorder is a heterogeneous ...

Claims

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Application Information

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IPC IPC(8): A01K67/02A61K49/00
CPCA01K67/02A61K49/0008
Inventor 李扬郭飞张兵
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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