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A kind of hygroscopic antibacterial 3D nanofiber medical dressing and preparation method thereof

A nanofiber, 3D technology, applied in absorbent pads, medical science, bandages, etc., can solve the problems of poor controllability of porosity and mechanical properties of fiber films, difficult to meet medical dressings, etc., and is conducive to wound healing and wound maintenance. Wetting, reducing the effect of springback stress

Active Publication Date: 2020-11-17
那坡同益新丝绸科技实业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen from the above prior art that by changing the conditions of electrospinning, a self-assembled three-dimensional stacked fiber film can be obtained, but the controllability of the porosity and mechanical properties of the fiber film is poor, and it is difficult to meet the requirements of medical dressings

Method used

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  • A kind of hygroscopic antibacterial 3D nanofiber medical dressing and preparation method thereof
  • A kind of hygroscopic antibacterial 3D nanofiber medical dressing and preparation method thereof
  • A kind of hygroscopic antibacterial 3D nanofiber medical dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] (1) Dissolve amoxicillin at 20 mg / mL in a mixed solution of acetone and N,N-dimethylformamide (wt / wt, 1 / 1), then dissolve PCL-PEG-PCL in a mixed solution of amoxicillin The mixed solution of moxicillin was fully dissolved at 25° C., and a spinning solution with a mass fraction of 25% PCL-PEG-PCL was prepared. The spinning solution was transferred to a 10mL syringe, the spinning voltage was 15kV, the spinning speed was 0.5mL / h, and the receiving distance was 12cm for spinning, and the drum collected the PCL-PEG-PCL nanofiber 2D film.

[0043] (2) Accurately weigh 15.429g of PCL-PEG-PCL nanofiber membrane, place it in a 500mL beaker, add a certain amount of distilled water, prepare a homogeneous solution with a concentration of 40mg / ml, and homogenize it at 15krpm 10min. 370mL nanofiber homogeneous solution was placed in a sealed container, cooled with liquid nitrogen for 15min, and vacuum-dried with a freeze dryer for 24h. The freeze-dried sample was placed in a glass ...

Embodiment 2

[0045] (1) Dissolve amoxicillin and vancomycin hydrochloride at 0.1 mg / ml in a mixed solution of acetone and N,N-dimethylformamide (wt / wt, 0.1 / 10), then PCL-PEG- PCL was dissolved in a mixed solution mixed with amoxicillin, fully dissolved at 30° C., and a spinning solution with a mass fraction of 15% PCL-PEG-PCL was prepared. The spinning solution was transferred to a 10mL syringe, the spinning voltage was 5kV, the spinning speed was 0.1mL, and the receiving distance was 5cm, and the PCL-PEG-PCL nanofiber 2D film was collected by the roller.

[0046] (2) Accurately weigh 15.429g of PCL-PEG-PCL nanofiber membrane, place it in a 500mL beaker, add a certain amount of tert-butanol, prepare a homogeneous solution with a concentration of 5mg / ml, and prepare it under the condition of 6krpm Homogenization for 12min. 370mL nanofiber homogeneous solution was placed in a sealed container, placed in a -10°C environment for 5min, and vacuum-dried with a freeze dryer for 12h. The freeze-...

Embodiment 3

[0048] (1) Dissolve amoxicillin and penicillin at 1 mg / mL in a mixed solution of acetone and N,N-dimethylformamide (wt / wt, 10 / 0.1), then dissolve PCL-PEG-PCL in the mixed solution A mixed solution of amoxicillin was prepared, fully dissolved at 0°C, and a spinning solution with a mass fraction of 35% PCL-PEG-PCL was prepared. The spinning solution was transferred to a 10mL syringe, the spinning voltage was 40kV, the spinning speed was 5mL / h, and the receiving distance was 25cm, and the PCL-PEG-PCL nanofiber 2D film was collected by the roller.

[0049] (2) Accurately weigh 15.429g of PCL-PEG-PCL nanofiber membrane, place it in a 500mL beaker, add a certain amount of tert-butanol to prepare a homogeneous solution with a concentration of 80mg / ml, and prepare it under the condition of 15krpm Homogenize for 15min. 370mL nanofiber homogeneous solution was placed in a sealed container, placed in -20°C environment for 15min, and vacuum-dried with a freeze dryer for 48h. The freeze-...

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Abstract

The invention provides a moisture absorption antibacterial 3D (Three-Dimensional) nanofiber medical dressing and a preparation method thereof. The moisture absorption antibacterial 3D nanofiber medical dressing is prepared from PCL (Polycaprolactone)-PEG (Polyethylene Glycol)-PCL short nanofiber and antibacterial medicine. The preparation method comprises the following steps: dissolving the antibacterial medicine in a mixed solution containing N-N-dimethyl formamide, adding a PCL-PEG-PCL copolymer, and dissolving, thus obtaining a spinning solution; transferring the spinning solution in an electrostatic spinning device, spinning and collecting, thus obtaining a nanofiber 2D (Two-Dimensional) membrane; adding the nanofiber 2D membrane in a solvent, and stirring at a high speed, thus obtaining a homogenizing solution; transferring the homogenizing solution into a sealed container, quickly cooling at a low temperature, carrying out freeze vacuum drying, and carrying out thermal treatment,thus obtaining the moisture absorption antibacterial 3D nanofiber medical dressing. The medical dressing prepared by the invention contains multi-stage holes and is consistent in anisotropy, firm instructure and excellent in moisture absorption performance and moisture retention performance, the structure is soft after moisture absorption, and the moisture absorption antibacterial 3D nanofiber medical dressing can be tightly fitted with a wound, is breathable and antibacterial and is suitable for being used as the medical dressing.

Description

technical field [0001] The invention belongs to the technical field of medical dressing materials, and in particular relates to a hygroscopic and antibacterial 3D nanofiber medical dressing and a preparation method thereof. Background technique [0002] At present, new medical dressings can be subdivided into film dressings, liquid dressings, hydrocolloid dressings, hydrogel dressings, alginate dressings and foam dressings. Their common feature is that they can provide a moist wound healing environment and absorb tissue Exudate, prevent wound infection, etc. Among them, nanofibers prepared by electrospinning are widely used in the field of biomedical dressings because of their large fiber aspect ratio, high specific surface area, good ductility, and controllable fiber composition. [0003] The porous structure of the electrospun nano antibacterial dressing makes it have good air permeability, and its pore size can be controlled to be small enough to block the invasion of ba...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/26A61L15/42A61L15/44A61L15/46A61L15/62
Inventor 于晖马江龙林敏伍秀敏蔡洁贾永堂
Owner 那坡同益新丝绸科技实业有限公司
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