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Composite film material for light-controlled release of nitric oxide, preparation method and application thereof

A light-controlled release, nitric oxide technology, applied in the field of biomedical engineering materials

Active Publication Date: 2020-04-14
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, by modifying the surface of gold composite membrane material (Au) with spherical dendritic polyamide-amine (N-N-PAMAM) as NO donor, and then coating with polycaprolactone (PCL), freeze-dried and pressed into Finally, a gold composite film material covering the surface is prepared. The spherical dendritic polyamide-amine is the matrix, and the outermost layer is polycaprolactone film material. The film composite material and the film composite material that release nitric oxide under near-infrared laser irradiation are controlled. Its application has not been reported

Method used

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  • Composite film material for light-controlled release of nitric oxide, preparation method and application thereof
  • Composite film material for light-controlled release of nitric oxide, preparation method and application thereof
  • Composite film material for light-controlled release of nitric oxide, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] (1) Synthesis of 3 generations of spherical dendritic polyamidoamines:

[0087] Dissolve ethylenediamine in methanol in an ice-water bath at 0°C, then drop it into the methanol solution of methyl acrylate, stir evenly, raise the temperature to 25°C and stir for 12 hours to obtain 0.5-generation ethylenediamine as the core PAMAM unit (N-N-P AMAM -D 0.5 ); N-N-PAMAM-D in an ice-water bath 0.5 Dissolve in methanol, drop into the methanol solution of ethylenediamine, stir evenly, raise the temperature to 25°C and stir for 12 hours to obtain the N-N-PAM AM motif (N-N-PAMAM-D 1 ); wherein, the molar ratio of ethylenediamine to methyl acrylate is 1:4; the N-N-PAMAM-D 0.5The molar ratio with ethylenediamine is 1:4; the consumption of described methyl alcohol is based on the methyl acrylate of every 10ml of methanol dissolved in 1ml; the consumption of described methyl alcohol is calculated in the ethylenediamine of every 10ml of methanol dissolved in 1ml; -PAMAM-D 0.5 The d...

Embodiment 2

[0091] (1) Synthesis of 3 generations of spherical dendritic polyamidoamines:

[0092] Dissolve ethylenediamine in methanol in an ice-water bath at 0°C, then drop it into the methanol solution of methyl acrylate, stir evenly, raise the temperature to 35°C and stir for 48 hours to obtain 0.5-generation ethylenediamine as the core PAMAM unit (N-N-PAMAM -D 0.5 ); N-N-PAMAM-D in an ice-water bath 0.5 Dissolve in methanol, drop into the methanol solution of ethylenediamine, stir evenly, raise the temperature to 35°C and stir for 48 hours to obtain the N-N-PAMAM unit (N-N-PAMAM-D 1 ); wherein, the molar ratio of ethylenediamine to methyl acrylate is 1:8; the N-N-PAMAM-D 0.5 The mol ratio with ethylenediamine is 1:12; The consumption of described methyl alcohol is based on the methyl acrylate of every 10ml methanol dissolution 5ml; The consumption of described methyl alcohol is the ethylenediamine of every 10ml methanol dissolution 5ml; The N-N- PAMAM-D 0.5 The dosage is 5g N-N-P...

Embodiment 3

[0096] (1) Synthesis of 3 generations of spherical dendritic polyamidoamines:

[0097] Dissolve ethylenediamine in methanol in an ice-water bath at 0°C, then drop it into the methanol solution of methyl acrylate, stir evenly, raise the temperature to 30°C and stir for 24 hours to obtain 0.5-generation ethylenediamine as the core PAMAM unit (N-N-PA MAM-D 0.5 ); N-N-PAMAM-D in an ice-water bath 0.5 Dissolve in methanol, drop into the methanol solution of ethylenediamine, stir evenly, raise the temperature to 35°C and stir for 24 hours to obtain the N-N-PAMA M motif (N-N-PAMAM-D 1 ); wherein, the molar ratio of ethylenediamine to methyl acrylate is 1:6; the N-N-PAMAM-D 0.5 The molar ratio with ethylenediamine is 1:8; The consumption of described methanol is based on the methyl acrylate of 3ml per 10ml of methanol; -PAMAM-D 0.5 The dosage is 2.5g N-N-PAMAM-D per milliliter of methanol 0.5 count.

[0098] (2) Synthesis of dendritic polyamide N-N-PAMAM with 3-generation ethyle...

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Abstract

The invention discloses a composite membrane material releasing nitric oxide under optical control as well as a preparation method and application thereof. The preparation method of the material comprises the following steps of firstly, synthesizing spherical branched polyamidoamine (N-N-PAMAM-D3), then modifying N-N-PAMAM-D3 on the surfaces of gold nano particles of uniform particle size so as toprepare N-N-PAMAM modified nano gold, then loading nitric oxide so as to obtain the composite membrane material releasing nitric oxide under optical control. The composite membrane material releasingnitric oxide under optical control is blended with polycaprolactone (PCL), and then the mixture is freeze dried and pressed into a membrane, so as to obtain a composite membrane material controlled to release nitric oxide under near infrared laser irradiation. The material is uniform in particle size, responds sensitively, loads and stores a large quantity of NO, can release NO for a long time, has better biocompatibility, and can be applied to the field of biomedical engineering materials. The material can inhibit bacteria and fungus from growing and proliferating, and can be used for preparing anti-bacteria medicines.

Description

technical field [0001] The invention belongs to the field of biomedical engineering materials, in particular to a composite film material for light-controlled release of nitric oxide, a preparation method and application thereof. Background technique [0002] Since Furchgott et al. discovered in 1980 that vascular endothelial cells can synthesize and secrete vascular endothelial-derived relaxing factor (EDRF), and in 1986 Furchgott and Ignarro independently proved that EDRF is NO, the basic and clinical research on NO has been vigorously developed, and NO has become One of the most compelling biomolecules of recent years. A large number of studies have shown that NO is an important biological messenger molecule, involved in vascular regulation, neurotransmission, inflammation and immune response, etc. It is widely distributed throughout the brain, blood vessels, immunity, lungs, reproductive organs and other organs. [0003] In recent years, it has been found that NO can de...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L79/02C08K3/08C08K3/28C08G73/02C08J5/18A61K33/00A61K41/00A61K9/70A61K47/34A61K47/59A61P31/04A61P31/10A61P17/02
CPCA61K9/7007A61K33/00A61K41/0052A61K47/34C08G73/028C08J5/18C08J2379/02C08K3/28C08K2003/0806C08K2201/011A61K2300/00
Inventor 马栋李国巍张武薛巍
Owner JINAN UNIVERSITY
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