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Composition of nuezhenoside, rhoifolin and hyperoside and purpose thereof

A technology of rhoside and hyperoside, which is applied in the field of privetin, rhoside, hyperoside composition and its application, and can solve the problems such as the undiscovered effect of drugs for the neurodegenerative diseases of the cymbidium round leaf

Inactive Publication Date: 2018-01-05
JIANGSU T MAB BIOPHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] At present, it has not been found that the main components of Shanxiang round leaves have the effect of treating and / or preventing neurodegenerative diseases

Method used

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  • Composition of nuezhenoside, rhoifolin and hyperoside and purpose thereof
  • Composition of nuezhenoside, rhoifolin and hyperoside and purpose thereof
  • Composition of nuezhenoside, rhoifolin and hyperoside and purpose thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: Preparation of privetin, rhodorin and hyperoside composition

[0029] Take 1,000g of the leaves of Cyperus japonica, add 12 times the amount of 70% ethanol for reflux extraction for 1.5 hours, filter, add 10 times the amount of 70% ethanol for reflux extraction for 1.5 hours, filter, combine the two extracts, recover the ethanol, and pass the aqueous solution through the The treated D101 macroporous resin column was eluted with water, 10% ethanol, 45% ethanol, and 1% sodium hydroxide solution respectively, and the eluted part of 45% ethanol was collected, concentrated under reduced pressure, and dried to obtain more than 30% privetin The mixed total glycosides of nitroside, rhodoside, and hyperoside are separated by silica gel column chromatography and Sephadex LH-20 column chromatography, respectively merged with privetin, rhodoside, and hyperin fractions, crystallized, and obtained Purity of chastinoside (3.5g, purity: 98.5%), rhoiferin (1.5g, purity: 98...

Embodiment 2

[0031] Mix privetin (14g), rhodorin (6g) and hyperoside (3.6g) in a ratio of 7:3:1.8, stir, grind, and mix uniformly to obtain privetin, rhodoside, and gold Serin composition (23.6g).

Embodiment 3

[0033] Mix privetin (10g), rhodorin (10g) and hyperoside (6g) in a ratio of 5:5:3, stir, grind, and mix uniformly to obtain privetin, rhodoside, and gold wire Audin Composition (26g).

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Abstract

The invention belongs to the field of medicine and relates to a composition of nuezhenoside, rhoifolin and hyperoside. Specially, the composition comprises, by weight, 40-90% of the nuezhenoside, 5-40% of the rhoifolin and 5-30% of the hyperoside, and the composition has good treatment and / or prevention effects on neurodegenerative diseases and can overcome side effect defects of existing medicine.

Description

technical field [0001] The invention relates to the application of a composition of privetin, rhodorin and hyperoside in the preparation of medicines for treating and / or preventing neurodegenerative diseases. Background technique [0002] Neurodegenerative diseases are diseases caused by central nervous system dysfunction caused by progressive degeneration and necrosis of nerve cells, which are aggravated with the aging of the global population, including Alzheimer's disease (AD) and Parkinson's disease (Parkinson's disease, PD), amyotrophic lateral sclerosis (Atrophy lateral sclerosis, ALS), Huntington's disease (Huntington's disease, HD), stroke (Stroke) and cardiovascular dementia (Vascular dementia, VD). It mainly affects the cognitive function and motor function of patients, causing disability and high mortality rate, and brings great psychological and economic burden to patients' families and society. [0003] At present, most neurodegenerative diseases do not have a ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P25/28A61P25/16A61P9/10
Inventor 孙文凯曾君南谢宁吴建彬程睿汤新乾刘艳红王章伟
Owner JIANGSU T MAB BIOPHARMA
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