Application of d-amino acid and its derivatives in anti-tobacco mosaic virus

A tobacco mosaic virus and anti-tobacco mosaic technology, which is applied in the application field of D-amino acid and its derivatives in anti-tobacco mosaic virus, can solve problems that have not been reported, and achieve industrialization, wide sources, good The effect of water solubility

Active Publication Date: 2018-05-25
山东博苑医药化学股份有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is worth mentioning that there is still no report on the anti-TMV activity of D-amino acids.

Method used

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  • Application of d-amino acid and its derivatives in anti-tobacco mosaic virus
  • Application of d-amino acid and its derivatives in anti-tobacco mosaic virus
  • Application of d-amino acid and its derivatives in anti-tobacco mosaic virus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 Conventional bioassays measure the activity against tobacco mosaic virus

[0018] 1. In vitro activity

[0019] Rub inoculation of leaves of Shanxi tobacco at the right age, rinse with running water, the virus concentration is 10 μg / mL. After drying, cut it off, cut it in half along the midrib of the leaf, soak the left and right half leaves in 1‰ Tween water and medicine, take it out after 30 minutes, and cultivate it under suitable light temperature for moisturizing, every 3 leaves is 1 repetition, repeat 3 times . After 3 days, record the number of lesions and calculate the control effect.

[0020] 2. In vivo protection:

[0021] Select Shanxi tobacco with uniform growth at the 3-5 leaf stage, spray the whole plant, and repeat each treatment 3 times, and set a 1‰ Tween 80 aqueous solution as a control. After 24 hours, sprinkle carborundum (500 mesh) on the leaf surface, dip the virus solution with a brush, and wipe the entire leaf surface twice along th...

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PUM

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Abstract

The invention provides an application of D-amino acid and D-amino acid derivatives to resistance of TMV (tobacco mosaic virus). The structural formula of the D-amino acid derivatives is shown as general formula I in the description, the anti-TMV activity of the D-amino acid and the D-amino acid derivatives is equivalent to or better than that of the commercialized variety virazole, further, the D-amino acid and the D-amino acid derivatives are not absorbed by a human body and are safer, and the D-amino acid is more stable than L-amino acid and is suitable for being used in the field. The D-amino acid and the D-amino acid derivatives have quite good anti-TMV activity (in the aspects of protection, treatment and passivation).

Description

technical field [0001] The invention relates to the application of D-amino acid and its derivatives in resisting plant tobacco mosaic virus. Background technique [0002] The stereoselectivity of monochiral pesticides is mainly reflected in the activity on target organisms and the adverse effects on non-target organisms. At the same time, the use of single-enantiomer pesticides will reduce the residual concentration of pesticides in the environment and change the residual composition of isomers, thereby reducing the pressure on the environment (Ecological Environment, 2008, 17, 1268–1275). [0003] Ryzkov et al first reported in 1951 that some L-amino acids could inhibit tobacco mosaic disease (Ryzkov, V, L. Dokl. Akad. Nauk. 1951, 80, 677-680). In 1953, Commoner et al. (Commoner, B.; Nehari, V.J. Gen. Physiol. 1953, 36, 791-805) studied the amino acid changes in tobacco infected with TMV. The contents of glutamine, asparagine, aspartic acid, glutamic acid, and serine in t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N37/44A01P1/00
CPCA01N37/44
Inventor 汪清民张斌李成林于国清
Owner 山东博苑医药化学股份有限公司
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