Modeling method of excitation and contraction processes of fast muscle fibers of skeletal muscle

Abstract

The invention discloses a modeling method of excitation and contraction processes of fast muscle fibers of skeletal muscle. The method includes the steps of (1) adopting half sarcomere as a unit and building an electrophysiologic mathematic model of fast muscle sarcolemma of the skeletal muscle; (2) adopting the half sarcomere as a unit and building a geometric model of calcium ions circulation; (3) building a mathematic model of a release process of calcium ions from a RyR channel on terminal pond; (4) building a mathematic model of combining calcium ions and magnesium ions with ATP and parvalbumin separately; (5) building a methematic model of cross-bridge power and a mathematic model of combination of the calcium ions and troponin; (6) building a sarcolemma fatigue model and a metabolism fatigue model during the excitation and contraction processes of the fast muscle fibers of the skeletal muscle. The modeling method of the excitation and contraction processes of the fast muscle fibers of the skeletal muscle is based on the biologic structure of the skeletal muscle, and can achieve building of mathematic models in each link, more precise analysis, simulation and prediction of the excitation and contraction processes of the sarcolemma of the skeletal muscle, and provide theoretical guidance for disease diagnoses and rehabilitation therapies of the skeletal muscle.

Description

technical field [0001] The invention relates to a modeling method for the excitation and contraction process of skeletal muscle fast muscle fibers. Background technique [0002] At present, there are many mathematical models for studying the excitation and contraction of skeletal muscle fibers, but these models are largely based on experience, cannot simulate the entire process of skeletal muscle excitation and contraction caused by electrical stimulation, and ignore the process of skeletal muscle excitation and contraction. Fatigue effects, without establishing a mathematical model based on the physiological mechanism, cannot accurately simulate and predict the excitation and contraction process of skeletal muscle fibers. Based on the above problems, it is necessary to establish a complete mathematical model that can describe the entire process of skeletal muscle excitation and contraction caused by electrical stimulation from a physiological mechanism. Contents of the in...

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the problem of not being able to simulate the entire process of skeletal muscle excitation and contraction caused by electrical stimulation, and ignoring the fatigue effect generated during the process of skeletal muscle excitation and contraction, without establishing a mathematical model based on physiological mechanisms, and being unable to accurately simulate and predict skeletal muscle fibers A method for modeling the excitation and contraction process of skeletal muscle fast muscle fibers

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