Intracranial radiotherapy and chemotherapy integration dual-chamber mother-daughter cyst

Abstract

The present invention provides an intracranial radiotherapy and chemotherapy integration dual-chamber mother-daughter cyst. The mother-daughter cyst comprises a mother-daughter dual-layer cyst, a dual-chamber pipeline and a drug supply pipeline, the mother-daughter dual-layer cyst comprises an outer wall and an inner wall, a gap arranged between the outer wall and the inner wall is subjected to inflation, and the internal portion of the inner wall is divided into a mother cyst and a daughter cyst which are not mutually communicated; the dual-chamber pipeline has an inner pipeline located in the internal portion and an outer pipeline wrapping the outer side of the inner pipeline to allow the inner pipeline to be communicated with the daughter cyst, and the outer pipeline is communicated with the mother cyst; and the drug supply pipeline comprises a radiotherapy pipeline and a chemotherapy pipeline, the radiotherapy pipeline is communicated with the inner pipeline, and the chemotherapy pipeline is communicated with the outer pipeline. Through combination of the dual-chamber mother-daughter cyst, the intracranial radiotherapy and chemotherapy integration dual-chamber mother-daughter cyst integrates the internal radiotherapy and the internal chemotherapy, effectively prevents radiotherapy and chemotherapy drugs from be leaked out from a puncture point, is suitable for integration treatment of the intracranial malignant tumor, especially for the internal radiotherapy and the internal chemotherapy application of the malignant brain glioma.

Description

technical field [0001] The invention relates to a dual-cavity mother-in-law capsule for intracranial tumor radiotherapy and chemotherapy, which is mainly used for patients who need further internal radiotherapy and internal chemotherapy after resection of intracranial malignant tumors. On the one hand, the device can be used to regularly improve the The radiation dose of internal radiotherapy, on the other hand, can regularly administer intratumoral chemotherapy drugs, and can make the internal chemotherapy drugs be distributed as evenly as possible. Background technique [0002] In the prior art, Liu Aijun invented the "Minimally Invasive Implantable Radiotherapy Capsule" in January 2008, which can complete the internal radiotherapy of tumors without the function of chemotherapy; in September 1992, Li Aimin invented the "Glioma Chemotherapy Capsule" , has the function of chemotherapy, but does not have the function of internal radiotherapy; in 2012, Zhang Lei invented "A Mu...

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Problems solved by technology

[0005] 1. Intracranial radiotherapy and chemotherapy cannot be completed by one device at the same time;

[0006] 2. In terms of radiotherapy: 1) In order to protect normal brain tissue, the radiotherapy dose of conventional radiotherapy should not exceed 60Gy. For some tumors, it is difficult to reach the lethal dose of radiation, and there is a disadvantage of insufficient dose; 2) The radiation source implanted with radioactive particles has attenuation , the radiation dose is difficult to keep stable for a long time, and its replacement and removal often require craniotomy, which is poor in repeatability. In addition, due to the changeable surgical conditions, the implementation of the radiation treatment plan has certain uncertainties;

[0007] 3. In terms of chemotherapy: 1) Due to the existence of the blood-brain barrier in conventional systemic chemotherapy, it is difficult to achieve a high blood concentration in the brain; Inhomogeneous drug distribution; lumbar puncture administration is complicated, and there are still disadvantages such as lumbar injury, increased nerve root, spinal cord chemical injury, and spinal cord suppression; in addition, the internal chemotherapy capsules reported and invented in the past are all tubular heads, and the drug administration has the advantages of Disadvantages of small and uneven distribution area;

[0008] 4. In the previous puncture chemotherapy capsule (single-layer capsule wall) for chemotherapy, there was a risk of leakage of radiotherapy and chemotherapy drugs from the puncture point;

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