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A kind of wound gel for promoting healing and preparation method thereof

A gel and wound technology, applied in the field of healing-promoting wound gel and its preparation, to achieve the effects of reducing synthesis and release, accelerating growth and promoting proliferation

Inactive Publication Date: 2020-06-23
GUANGDONG TAIBAO MEDICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

General gel dressings need to meet performance requirements such as certain strength, control and absorption of exudate, moisturizing, antibacterial, anti-inflammatory, non-toxic, harmless and non-irritating, but the existing medical hydrogels, especially alginate hydrogels, are difficult while meeting these requirements

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Preparation of amorphous gel:

[0035](1) Preparation of oxidized alginate: Take 5 parts by weight of sodium alginate and dissolve it in water to prepare an aqueous solution with a mass fraction of 1%, and use 3 parts of 0.28mol / L sodium periodate solution to avoid light oxidation After 36 hours, add 0.8 parts of ethylene glycol to terminate the oxidation reaction, add 0.1 parts of NaCl and mix well, then add 75 parts of ethanol, and wait for precipitation;

[0036] (2) Preparation of liquid A: Weigh 8 parts of carbomer, 12 parts of maltooligosaccharide, 0.1 part of phenytoin, 5 parts of transdermal absorption enhancer synthetic borneol, and 20 parts of glycerin by weight, and add 50 parts of purified water Stir at room temperature until it is completely wetted, and filter off the insoluble matter by hot filtration to obtain liquid A;

[0037] (3) Cross-linking reaction: Take 0.5 parts by weight of the oxidized alginate prepared above, add 10 parts of 2-(N-morpholine)e...

Embodiment 2

[0040] Preparation of amorphous gel:

[0041] (1) Preparation of oxidized alginate: Take 7 parts by weight of the alginate potassium alginate and dissolve it in water to prepare an aqueous solution with a mass fraction of 4%, and use 4 parts of 0.25mol / L sodium periodate solution After 24 hours of oxidation in the dark, add 1 part of ethylene glycol to terminate the oxidation reaction, add 0.3 parts of NaCl and mix well, then add 100 parts of ethanol, and wait for precipitation;

[0042] (2) Preparation of liquid A: Weigh 6 parts of carbomer, 10 parts of maltooligosaccharide, 10 parts of phenytoin sodium, 20 parts of transdermal absorption enhancer polyethylene glycol, and 5 parts of humectant propylene glycol by weight, and add purified After 40 parts of water, stir at room temperature until it is completely wetted, and filter out the insoluble matter by hot filtration to obtain liquid A;

[0043] (3) Cross-linking reaction: Take 0.4 parts by weight of the oxidized alginate ...

Embodiment 3

[0046] Preparation of solid flake gel:

[0047] (1) Preparation of oxidized alginate: Dissolve 10 parts by weight of alginate ammonium alginate in water and prepare an aqueous solution with a mass fraction of 5%, and use 1 part of 0.3mol / L sodium periodate solution After oxidizing in dark for 48 hours, add 0.1 part of ethylene glycol to terminate the oxidation reaction, add 0.5 part of NaCl and mix well, then add 60 parts of ethanol, and wait for precipitation;

[0048] (2) Preparation of liquid A: Weigh 10 parts of carbomer, 15 parts of maltooligosaccharide, 5 parts of phenytoin, 10 parts of transdermal absorption accelerator propylene glycol, 10 parts of dimethyl sulfoxide, and humectant mannitol according to parts by weight. 10 parts, add 60 parts of purified water, stir at room temperature until completely wet, heat filter to remove insoluble matter, and obtain A liquid;

[0049] (3) Cross-linking reaction: Take 0.3 parts by weight of the oxidized alginate prepared above,...

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Abstract

The invention relates to wound healing promoting gel and a preparation method thereof. The wound healing promoting gel is prepared by forming a gel matrix by oxidized alginate and diamine or diamidogen matters through a cross-linking reaction and compounding the following components in parts by weight: 5 to 10 parts of carbomer, 10 to 20 parts of isomalto-oligosaccharide, 0.1 to 10 parts of a wound healing promoting drug, 5 to 20 parts of a skin penetration enhancer and 40 to 70 parts of purified water. According to the wound healing promoting gel disclosed by the invention, after alginate is partially oxidized by sodium periodate which is subjected to a specific technology, carboxyl active genes in alginic acid can be activated, occurrence of the cross-linking reaction can be quickened, and the production efficiency of the gel is increased; alginate gel prepared by the invention has higher cohesive energy, is easy to form and not easy to crack, can be suitable for wounds in any parts, and is also capable of inhibiting reproduction of in-vivo harmful bacteria and generation of poisonous corrupt matters, expressing the effects of stopping bleeding, resisting bacteria, clearing wounds and promoting wound healing, and greatly shortening the healing time of the wounds.

Description

technical field [0001] The invention relates to the technical field of medical consumables, in particular to a healing-promoting wound gel and a preparation method thereof. Background technique [0002] When the skin and mucous membrane are injured, a suitable dressing should be selected to cover the wound. It can maintain a moist environment for the wound, absorb secretions, relieve pain and control bleeding, thereby promoting rapid wound healing. Studies have shown that wounds heal twice as fast in wet environments as in dry environments, leading to new insights into the wound healing process. Although the healing time of wounds can be shortened under moist conditions, the new dressings developed from this show certain differences in healing speed, and it is difficult to meet the nursing needs of complex wounds. Therefore, it is a new development trend to seek a dressing that can efficiently promote wound healing. [0003] Alginate, also known as algin and alginic acid, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K47/36A61K31/4166A61P17/02C08B37/04
CPCA61K9/0014A61K9/06A61K31/4166A61K47/36C08B37/0084
Inventor 卢亢陈锦涛熊亮
Owner GUANGDONG TAIBAO MEDICAL SCI TECH
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