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Biomarker of active pulmonary tuberculosis

A technology of active pulmonary tuberculosis and biomarkers, applied in the field of biomarkers, to achieve the effect of facilitating the development of new drugs

Active Publication Date: 2017-08-08
GUANGDONG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Expression of cANRIL may be associated with transcription of INK4 / ARF and risk of cardiovascular sclerosis, study finds

Method used

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  • Biomarker of active pulmonary tuberculosis
  • Biomarker of active pulmonary tuberculosis
  • Biomarker of active pulmonary tuberculosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A biomarker of active pulmonary tuberculosis, at least one selected from the following six circRNAs: hsa_circ_0005836, hsa_circ_0009128, hsa_circ_0003519, hsa_circ_0023956, hsa_circ_0078768, hsa_circ_0088452.

[0030] Among them, among the six circRNAs mentioned above, the down-regulation of hsa_circ_0005836 was the most obvious.

[0031] Among them, the expression of hsa_circ_0005836 was down-regulated by 3.027 times, among which, P<0.0001.

[0032] Wherein, the aforementioned biomarkers indicate early active pulmonary tuberculosis.

Embodiment 2

[0034] A drug for treating active pulmonary tuberculosis, which is a drug developed by using the biomarker of active pulmonary tuberculosis in Example 1 as a therapeutic target.

Embodiment 3

[0036] A kit for predicting whether a subject with active pulmonary tuberculosis will benefit from adjuvant therapy, characterized in that: the kit includes a variety of reagents for measuring the expression of a biomarker for active pulmonary tuberculosis in Example 1 , and includes a tool for analyzing said expression and generating a risk score to predict whether a patient will benefit from adjuvant therapy.

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Abstract

The invention relates to the technical field of biomarkers, in particular to a biomarker of active pulmonary tuberculosis. The biomarker of active pulmonary tuberculosis is selected from at least one of the following six circRNAs: hsa_circ_0005836, hsa_circ_0009128, hsa_circ_0003519, hsa_circ_0023956, hsa_circ_0078768, hsa_circ_0088452. Specifically, hsa_circ_0005836 has the most obvious down-regulated expression. The biomarker of active pulmonary tuberculosis can be used as a therapeutic target, and is beneficial to development of new drugs.

Description

technical field [0001] The invention relates to the technical field of biomarkers, in particular to a biomarker of active pulmonary tuberculosis. Background technique [0002] Since the end of the last century, tuberculosis has once again become a public health problem that seriously threatens human health. In recent years, although the development trend of tuberculosis has been curbed, the number of new cases is still high every year. According to the latest WHO data, in 2016, tuberculosis killed 1.5 million people, including about 890,000 men, 480,000 women and 140,000 children. In recent years, although almost all cases are eventually curable, active pulmonary tuberculosis (APTB) remains one of the greatest threats to humanity and has great significance in the field of public health. Future goals should focus on reducing the incidence of active tuberculosis, not just new drug development. Early accurate diagnosis and timely treatment are the key to TB control. At pres...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68C12N15/11A61K45/00A61P11/00A61P31/06
Inventor 徐军发罗厚龙庄泽刚张俊爱卢远彬
Owner GUANGDONG MEDICAL UNIV
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