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Preparation method and application of indocyanine green J aggregate

A technology of indocyanine green and aggregates, which is applied in the field of medicine, can solve problems such as biological safety doubts, clinical application restrictions, and limited transformation applications, and achieves a simple preparation method, good photothermal effect, and strong safety. Effect

Inactive Publication Date: 2017-06-30
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of these nanomaterials are non-degradable or degraded into heavy metal ions in the body, their biological safety to organisms is questioned, and their clinical application is limited.
In addition, there are still many problems to be solved in the industrial production of these materials, which also limits their clinical transformation and application.

Method used

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  • Preparation method and application of indocyanine green J aggregate
  • Preparation method and application of indocyanine green J aggregate
  • Preparation method and application of indocyanine green J aggregate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Heat 1.5mM indocyanine green solution in a water bath at 62°C for 20h to obtain a solution of indocyanine green J aggregates, and filter the obtained solution to remove particles with a particle size greater than 100nm to obtain nanoscale indocyanine green J aggregates body. The obtained indocyanine green J aggregate solution is divided into vials, and placed on a freeze dryer to freeze-dry to obtain powdered indocyanine green J aggregates.

Embodiment 2

[0032] Heat 1mM indocyanine green solution in a water bath at 75°C for 12h, adjust the oxygen content in the gas above the solution to 1%, to obtain a solution of indocyanine green J aggregates, and filter the obtained solution to remove particles with a particle size greater than 100nm , to obtain nanoscale indocyanine green J aggregates. The obtained indocyanine green J aggregate solution is divided into vials, and placed on a freeze dryer to freeze-dry to obtain powdered indocyanine green J aggregates.

Embodiment 3

[0034] Heat 2mM indocyanine green solution in a water bath at 55°C for 36h, adjust the oxygen content in the gas above the solution to 2%, to obtain a solution of indocyanine green J aggregates, and filter the obtained solution to remove particles with a particle size greater than 100nm , to obtain nanoscale indocyanine green J aggregates. Add an empty liposome solution to the above solution, then heat and sonicate to obtain a liposome solution encapsulating indocyanine green J aggregates. The obtained liposome solution encapsulating indocyanine green J aggregates was divided into vials, and placed on a freeze dryer to freeze-dry to obtain powdered indocyanine green J aggregates.

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PUM

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Abstract

The invention provides a preparation method and application of an indocyanine green J aggregate. The indocyanine green J aggregate is used as a photothermal therapeutic agent, and has the advantages of simple preparation method, strong safety and good photothermal effect.

Description

technical field [0001] The invention belongs to the technical field of medicine and specifically designs a preparation method and application of indocyanine green J aggregates Background technique [0002] Photothermal therapy for tumors is a new tumor treatment method that has emerged in recent years. It mainly uses light energy to directly irradiate the tumor site to increase the local temperature to kill tumor cells, which greatly reduces systemic toxicity. Treatment is regarded as one of the technologies with great potential to replace traditional treatment methods such as surgery and chemotherapy. To improve the efficiency and tumor selectivity of laser-induced photothermal therapy, photothermal therapeutic agents with light-absorbing properties are usually introduced into tumor sites. Since near-infrared light (wavelength 650-950nm) has stronger tissue penetration ability, and the longer the wavelength, the stronger the penetration ability, so the ideal photothermal t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K49/00A61P35/00
CPCA61K41/0052A61K49/0034
Inventor 戴志飞刘仁发
Owner PEKING UNIV
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