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Biflavone-nickel complex and its preparation method and application

A technology of nickel complexes and biflavones, which is applied in the fields of medicine and organic synthesis, and can solve the problems of unreported research on the biological activity of bisflavone complexes

Inactive Publication Date: 2019-11-12
NANJING FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, so far, the research on the synthesis and biological activity of biflavone complexes has not been reported

Method used

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  • Biflavone-nickel complex and its preparation method and application
  • Biflavone-nickel complex and its preparation method and application
  • Biflavone-nickel complex and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Accurately weigh 53.8mg of Ame in a round bottom flask, dissolve it with 5mL of ethanol, accurately weigh 14.5mg of nickel nitrate hexahydrate, add it to 5mL of ethanol, add the nickel nitrate solution dropwise to the Ame solution, and add dropwise to the reaction solution Ethanol-ammonia water (V / V, 3:1) solution, adjust the pH to 6, keep at 30°C for 4-5 hours to react, precipitate, filter, wash with ethanol and water in turn, recrystallize in DMSO, and freeze-dry to obtain the Ame-Ni complex thing.

Embodiment 2

[0041] Accurately weigh 53.8 mg of Ame in a round bottom flask, dissolve it with 5 mL of 90% ethanol, accurately weigh 14.5 mg of nickel nitrate hexahydrate, dissolve it with 5 mL of 90% ethanol, add the nickel nitrate solution dropwise to the Ame solution, and add to the reaction solution Add ethanol-sodium ethoxide solution dropwise to adjust the pH to 5, keep at 30°C for 4-5h, precipitate, filter, wash with ethanol and water successively, recrystallize in DMSO, and freeze-dry to obtain the Ame-Ni complex.

Embodiment 3

[0043] Accurately weigh 53.8mg of Ame into a round bottom flask, dissolve it in 5mL of methanol, accurately weigh 14.5mg of nickel nitrate hexahydrate, dissolve it in 5mL of methanol, add the nickel nitrate solution dropwise into the Ame solution, and add methanol dropwise into the reaction solution - Sodium methoxide solution, adjust the pH to 7, keep at 40°C for 3-4 hours to react, a precipitate occurs, filter, wash with methanol and water successively, recrystallize in DMSO, and freeze-dry to obtain the Ame-Ni complex.

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Abstract

The invention discloses a biflavone-nickel complex, a preparation method and application thereof. In the present invention, the biflavone-nickel complex is obtained by reacting the biflavone-nickel complex with the biflavone as the ligand and the nickel ion as the central ion, and the structure of the complex is characterized by infrared spectrum, ultraviolet-visible absorption spectrum and high-resolution mass spectrum. At the same time, the present invention studies the anti-tumor and anti-oxidation activities of the biflavone-nickel complex. The MTT method showed that the amiflavone-nickel complex had better anti-tumor activity, and the anti-tumor activity was stronger than that of the amiflavone. The antioxidative activity is stronger than the biflavone itself. The formation of biflavonoid-nickel complexes can improve the antitumor and antioxidative activities of biflavonoids in Spirocarpus, which is expected to be used in the development of drugs.

Description

technical field [0001] The invention belongs to the technical fields of organic synthesis and medicine, and specifically relates to a biflavone-nickel complex and a preparation method and application thereof. Background technique [0002] Biflavonoids are unique chemical components of gymnosperms, such as Ginkgo biloba and Selaginella, which have biological activities such as anti-oxidation, anti-inflammation, anti-virus, and anti-tumor. Wherein, Amentoflavone (Amentoflavone, Ame) is a relatively common one in the amentoflavone compounds, and its structural formula is as follows: [0003] [0004] Sun et al. found that amentoflavone increased the expression of anti-cancer genes by activating hPPARγ, thereby achieving the effect of inhibiting breast cancer cells and cervical cancer cells [Lee E., Shin S., Lee J. et al. Cytotoxic activities of amentoflavone against human Breast and cervical cancers are mediated by increasing of pten expression levels due to peroxisome prol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F15/04A61P35/00A61P39/06
CPCC07F15/045
Inventor 曹福亮杨世龙徐莉唐颖周梦怡卢雯赵俸艺蒋国斌
Owner NANJING FORESTRY UNIV
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