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Anticancer peptide as well as preparation method and application thereof

An anti-cancer peptide, cancer cell technology, applied in the field of biomedicine

Active Publication Date: 2017-06-13
贵州源熙生物研发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the resistance of tumor cells to ACPs has not been reported, the resistance of some pathogenic bacteria, such as Streptococcus, Staphylococci and Enterococcus faecalis, to AMPs has been reported

Method used

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  • Anticancer peptide as well as preparation method and application thereof
  • Anticancer peptide as well as preparation method and application thereof
  • Anticancer peptide as well as preparation method and application thereof

Examples

Experimental program
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Embodiment Construction

[0053] Embodiments of the present invention will be described in detail below in conjunction with examples, but those skilled in the art will understand that the following examples are only for illustrating the present invention, and should not be considered as limiting the scope of the present invention. Those who do not indicate the specific conditions in the examples are carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used were not indicated by the manufacturer, and they were all conventional products that could be purchased from the market.

[0054] In this example, the anticancer peptide transformation method provided by the present invention is discussed by taking the antibacterial peptide CMAP-8 as an example.

[0055] 1. Materials and methods

[0056] 1.1 Materials

[0057] 1.1.1 Database

[0058] APD (http: / / aps.unmc.edu / AP / ), used to calculate the net charge and hydrophobicity of pep...

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Abstract

The invention relates to the field of biological medicines and particularly relates to an anticancer peptide. The anticancer peptide is selected from one or two of the following sequences in the following groups: (a) an amino acid sequence expressed as SEQ ID NO: 1; and (b) an amino acid sequence expressed as SEQ ID NO: 2. The anticancer peptide has extremely obvious anticancer activity, is low in toxicity and is relatively safe to human body. The invention also relates to a preparation method of the anticancer peptide and application of the anticancer peptide to preparation of anticancer medicines.

Description

technical field [0001] The present invention relates to the field of biomedicine, in particular to an anticancer peptide and its preparation method and application. Background technique [0002] Breast cancer is the most common cancer among women, with 1.38 million new breast cancer patients each year. According to the WHO survey, in 2014, the number of breast cancer patients in Chinese women reached 187,213, ranking second among all types of cancer in women. [0003] Chemotherapy is currently a standard treatment for most cancers. Known chemotherapy drugs that can treat breast cancer include natural active ingredients (such as paclitaxel, curcumin, vincristine, apigenin, and arsenic trioxide, etc.) and chemical drugs (such as cyclophosphamide, capecitabine, 5-fluorouracil, etc.). Due to the different molecular phenotypes of breast cancer, the sensitivity to the same drug or therapy also varies greatly, and the immunogenicity of breast cancer with different phenotypes is a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/08C12N15/11C12N15/70A61K38/10A61P35/00
CPCA61K38/00C07K7/08C12N15/70C12N2800/101
Inventor 周礼红
Owner 贵州源熙生物研发有限公司
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