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A simulation system for simulating fracture healing process

A simulation system and fracture healing technology, applied in the field of biomedical engineering, can solve the problems that mechanical factors do not have a deterministic relationship in cell differentiation, do not consider changes in the shape and size of callus, and the settings of models and biological materials are too simplified. Achieve the effect of avoiding humanitarian disputes, reducing biological experiments, and reducing delayed healing

Inactive Publication Date: 2017-12-08
HARBIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1. No individualized model for patients has been established;
[0005] 2. Many studies on fracture healing only stay at the tissue level, and there is no research on the cell activity in the fracture area;
[0006] 3. There is no definite relationship between mechanical factors and cell differentiation;
[0007] 4. The change in shape and size of callus during fracture healing is not considered;
[0008] 5. The model and biological material settings of the fracture site are too simplified

Method used

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  • A simulation system for simulating fracture healing process
  • A simulation system for simulating fracture healing process
  • A simulation system for simulating fracture healing process

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specific Embodiment approach 1

[0030] Specific implementation mode one: as figure 1 As shown, a simulation system for simulating the fracture healing process described in this embodiment includes: a three-dimensional geometric modeling module for fracture parts, a finite element modeling module for fracture parts, a biomechanical modeling module for fracture parts, and a cell evolution modeling module for fracture parts module, callus growth modeling module and display module;

[0031] The three-dimensional geometric modeling module of the fracture site is used to establish a three-dimensional surface geometric model of the fracture site after image preprocessing according to the imported two-dimensional tomographic image data;

[0032] The finite element modeling module of the fracture site is used for meshing the obtained three-dimensional surface geometric model of the fracture site, realizing the discretization of the continuous three-dimensional geometric model, and obtaining node coordinates and unit ...

specific Embodiment approach 2

[0037] Specific implementation mode two: as figure 2 As shown, in this embodiment, the specific process of the three-dimensional geometric modeling module of the fracture site to realize its function is:

[0038] Using the segmentation-based 3D medical image surface reconstruction algorithm to reconstruct the 3D surface of the image, and obtain the 3D surface geometric model through the process of threshold screening, interactive segmentation and 3D reconstruction;

[0039] The image is obtained by imaging equipment CT, and the data storage format is DICOM.

[0040] Other components and connections of this embodiment are the same as those of Embodiment 1.

specific Embodiment approach 3

[0041] Specific implementation mode three: as image 3 As shown, in this embodiment, the specific process of the fracture site finite element modeling module to realize its function is as follows:

[0042] The established three-dimensional surface geometric model is meshed, the continuous three-dimensional geometric model is discretized, and the node coordinates and unit numbers are obtained; the cell concentration and tissue volume fraction are stored in the unit nodes, and together with the node coordinates constitute the node information; Node information and element numbers form the required three-dimensional finite element model of the fracture site;

[0043] The meshing includes two steps of surface meshing and volume meshing; the surface meshing process is used to optimize the three-dimensional surface model, including: surface model optimization, smoothing, repairing loopholes; surface model optimization It is realized by reducing the triangular surface of the surface...

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Abstract

The invention discloses a simulation system for simulating a fracture healing process, which relates to the field of biochemical engineering. The simulation system is used for predicting the complex process of fracture healing and providing guidance for doctors in establishing a good surgical program for fracture healing. The system comprises a three-dimensional geometric modeling module, a finite element creation module, a fracture site biomechanical-modeling module, a fracture site cell evolution modeling module, a callus growth modeling module and a display module. Cell concentration and tissue material properties are updated by the fracture site biomechanical-modeling module and the fracture site cell evolution modeling module; the geometric shape of callus is updated by the callus growth modeling module; and the effect of fracture healing is judged by the display module. The simulation system can more accurately simulate the process of fracture healing and repetitively carry out experimental simulation for unlimited times, thus providing help for making the best surgical program for fracture healing.

Description

technical field [0001] The invention relates to the field of biomedical engineering, in particular to a simulation system for simulating the fracture healing process. Background technique [0002] The musculoskeletal system plays an important role in the human body, and its main functions include: motor function, protective function, support function, hematopoietic function, and storage function. The high incidence of fractures, the pain caused by fractures to patients and the economic burden on society make the study of fracture healing particularly urgent and important. Although the research on fracture healing has been paid much attention, there are still 5% to 10% of fractures with delayed union or even nonunion due to various reasons. [0003] Fracture healing is a complex process, including migration, proliferation, differentiation and apoptosis of bone marrow mesenchymal stem cells. Bone marrow mesenchymal stem cells differentiate into fibroblasts, chondrocytes, and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G06F17/50G06T17/30
CPCG06F30/23G06T17/30
Inventor 王沫楠杨宁王新宇
Owner HARBIN UNIV OF SCI & TECH
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