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Preparation and application of Raman enhancer

An enhancer and Raman technology, applied in the field of materials, can solve the problems of limited adsorption and Raman enhancement performance, few hot spots, etc., to achieve the effect of enhancing Raman detection signal, enhancing Raman signal, and increasing contact area

Active Publication Date: 2017-05-24
南京简智仪器设备有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Existing literature and patents (such as CN 103127890) have reported a kind of MF / Ag-NPs composite microspheres with Raman enhancement effect with melamine resin microspheres as the core and silver nanoparticles as the shell. The microspheres reported in this patent , the surface is evenly covered with a layer of silver nanoparticles, and a single microsphere can be used as a Raman-enhanced substrate, but there are problems such as few hot spots, and the adsorption and Raman enhancement performance is limited.

Method used

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  • Preparation and application of Raman enhancer
  • Preparation and application of Raman enhancer
  • Preparation and application of Raman enhancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: Preparation of PS microspheres with a size of 2 μm, modified Cu nanoparticles and Au nanoparticles, for the detection of paraquat.

[0024] (1) Preparation of PS microspheres

[0025] Stir 20 parts of St, 3 parts of PVP, 0.5 parts of AIBN, and 80 parts of ethanol in a container evenly, pass nitrogen gas for deoxygenation for 30 minutes, heat to 70°C, and react for 12 hours to obtain a white solid. Dried to obtain polystyrene microspheres, set aside.

[0026] (2) PS pretreatment

[0027] Add 1 g PS to concentrated H 2 SO 4 After sonicating for 30 min, centrifuge, then add 4 g / L PdCl 2 , 20 mL / L HCl, ultrasonicated for 30 min, centrifuged, and dried to obtain activated PS.

[0028] (3) Preparation of Cu-PS

[0029] Disperse the activated PS into 0.06M CuSO 4 • 5H 2 O, 12 mL / L HCHO, 0.06M Na 2 In a pH 12 solution composed of EDTA, ultrasonically reacted at 30°C for 15 min, washed and dried.

[0030] (4) Preparation of Au / Cu-PS

[0031] Add 0.1 g Cu-PS...

Embodiment 2

[0034] Example 2: Preparation of PS microspheres with a size of 3 μm, modified Cu nanoparticles and Au nanoparticles, for detecting rhodamine B.

[0035] (1) Preparation of PS microspheres

[0036] Stir 20 parts of St, 2 parts of PVP, 0.5 parts of AIBN, and 80 parts of ethanol in a container evenly, pass nitrogen gas for deoxygenation for 30 minutes, heat to 70°C, and react for 15 hours to obtain a white solid, which is washed with ethanol three times, at 50°C Dried to obtain polystyrene microspheres, set aside.

[0037] (2) PS pretreatment

[0038] Add 1 g PS to concentrated H 2 SO 4 After sonicating for 30 min, centrifuge, then add 4 g / L PdCl 2 , 20 mL / L HCl, ultrasonicated for 30 min, centrifuged, and dried to obtain activated PS.

[0039] (3) Preparation of Cu-PS

[0040] Disperse the activated PS into 0.05M CuSO 4 • 5H 2 O, 12 mL / L HCHO, 0.08 M Na 2 In a solution of pH 12 composed of EDTA, ultrasonically reacted at 35°C for 15 min, washed and dried.

[0041] (4)...

Embodiment 3

[0046] PS microspheres with a size of 5 μm were prepared and modified with Cu nanoparticles and Au nanoparticles for the detection of sildenafil.

[0047] (1) Preparation of PS microspheres

[0048] Stir 40 parts of St, 4 parts of PVP, 0.6 parts of AIBN, and 60 parts of ethanol in a container evenly, pass nitrogen gas for deoxygenation for 30 minutes, heat to 70°C, and react for 16 hours to obtain a white solid. Dried to obtain polystyrene microspheres, set aside.

[0049] (2) PS pretreatment

[0050] Add 1 g PS to concentrated H 2 SO 4 After sonicating for 30 min, centrifuge, then add 4 g / L PdCl 2 , 20 mL / L HCl, ultrasonicated for 30 min, centrifuged, and dried to obtain activated PS.

[0051] (3) Preparation of Cu-PS

[0052] Disperse the activated PS into 0.08M CuSO 4 • 5H 2 O, 12 mL / L HCHO, 0.08 M Na 2 In a solution of pH 12 composed of EDTA, ultrasonically reacted at 35°C for 15 min, washed and dried.

[0053] (4) Preparation of Au / Cu-PS

[0054] Add 0.1 g Cu-P...

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Abstract

The invention belongs to the technical field of functional materials, and relates to a preparation method and application of a Raman enhancer. The Raman enhancer is a microsphere with a Raman enhancement effect, PS microspheres form the core, and Au / Cu nanoparticles form the shell. The preparation method comprises the following steps: preparing the PS microspheres, depositing Cu on the surfaces of the PS microspheres to obtain Cu-PS by virtue of an in-situ chemical reduction method after activation treatment, and reducing chloroauric acid with sodium citrate to generate a gold nanoparticle for deposition on the Cu-PS, thereby preparing a Au / Cu-PS composite microsphere. According to the prepared Au / Cu-PS composite microsphere, the Au / Cu nanoparticles are non-uniformly distributed on the surface of the PS microsphere to form relatively many hotspot positions, and after a background signal is cancelled through a program, so that a Raman signal can be greatly enhanced. The preparation method is easy to operate and controllable in process, and the prepared Au / Cu-PS composite microsphere can be used for Raman detection in food safety and environmental safety.

Description

technical field [0001] The invention belongs to the technical field of materials and relates to functional materials, in particular to a preparation method and application of a reinforcing agent with Raman enhancing performance. Background technique [0002] Raman spectroscopy was discovered in 1928 and won the Nobel Prize in Physics in 1930. It is ubiquitous in all molecules and can reliably provide molecular structure information without being affected by solvents such as water. With the use of laser light sources, laser pull Mann spectroscopy has become an important tool for compound analysis. However, the signal intensity of Raman spectroscopy itself is very low, which greatly limits its detection sensitivity and detection range. Surface-enhanced Raman scattering spectroscopy (SERS) technology can significantly enhance the Raman signal and significantly improve its detection sensitivity. The enhancement effect of SERS is mainly due to the fact that the molecules to be t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 殷磊王鹏夏静竹
Owner 南京简智仪器设备有限公司
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