Medicine injected at Zusanli acupoint for treating diabetic foot and preparation method of medicine

A technology of diabetic foot and medicine, applied in the field of Lemahui injection and its preparation, can solve the problems of difficult tissue healing, palliative but not root cause, and inability to fundamentally cure diabetic foot

Active Publication Date: 2017-05-10
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Flexion of the proximal interphalangeal joint increases the risk of ulceration on the dorsal side of the protruding interphalangeal joint and on the plantar side of the toe tip, and vascular disease makes healing of damaged tissue difficult
[0004] In the prior art, the medicament for treating diabetic foot is mainly external rubbing ointment, which achieves the effect of local treatment of diabetic foot by promoting blood circulation and sterilizing.

Method used

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  • Medicine injected at Zusanli acupoint for treating diabetic foot and preparation method of medicine
  • Medicine injected at Zusanli acupoint for treating diabetic foot and preparation method of medicine
  • Medicine injected at Zusanli acupoint for treating diabetic foot and preparation method of medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A Lemahui injection for treating diabetic foot is composed of Lemahui extract accounting for 5% of the total volume of the injection, sodium chloride, glycine, glycine, sorbitol, citric acid and water.

[0037] A preparation method of Lemahui injection for treating diabetic foot, the steps are as follows:

[0038] (1) Take 100g of dried Lemon, add 3 to 8 times the concentration of 65 to 85% ethanol aqueous solution, heat up to 80 to 100°C, heat and reflux for extraction for 0.5 to 2 hours, then cool and filter to obtain the extract and For medicinal residues, repeat the above operation twice for medicinal residues, combine the obtained medicinal liquid for 3 times, and then distill under reduced pressure to obtain alcohol extracts;

[0039] (2) Add distilled water to the ethanol extract, mix well, let it stand for 3-5 hours, filter, take the supernatant, filter it with an ultrafiltration membrane, concentrate the filtrate, and obtain Lema with a relative density of 1.05...

Embodiment 2

[0043] A Lemahui injection for treating diabetic foot, consisting of Lemahui extract accounting for 5% of the total volume of the injection, sodium chloride, sulfobutyl-β-cyclodextrin, sorbitol, ethyl lactate, and water .

[0044] A preparation method of Lemahui injection for treating diabetic foot, the steps are as follows:

[0045] (1) Take 100g of dried Lemon, add 6 times the concentration of 65% ethanol aqueous solution, heat up to 80°C, heat and reflux for extraction for 0.5, then cool and filter to obtain extract and medicinal residues, repeat the above operation for medicinal residues 2 times, combining the medicinal liquid obtained 3 times, and then distilling under reduced pressure to obtain the alcohol extract;

[0046] (2) Add distilled water to the alcohol extract, mix well, let it stand for 3 hours, filter, take the supernatant, and then filter it with an ultrafiltration membrane, and concentrate the filtrate to obtain the initial extraction of Lema with a relati...

Embodiment 3

[0050] A Lemahui injection for treating diabetic foot is composed of 5% Lemahui extract, sodium chloride, glycerol and water.

[0051] A preparation method of Lemahui injection for treating diabetic foot, the steps are as follows:

[0052] (1) Take 100g of dried Lema, add 5 times the concentration of 75% ethanol aqueous solution, raise the temperature to 85°C, heat and reflux for 1.5 h, then cool and filter to obtain the extract and medicinal residues, repeat the above operation for medicinal residues 2 times, combining the medicinal solutions obtained in 3 times, and then distilling under reduced pressure to obtain the alcohol extract. The vacuum distillation process is -0.05 MPa, 60°C;

[0053] (2) Add distilled water to the alcohol extract, mix well, let it stand for 3 hours, filter, take the supernatant, and then filter it with a 3000 Dalton cyanoethyl cellulose acetate membrane for 24 hours to obtain a relative density of 1.15% of the original extract of Lema;

[0054] ...

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Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly relates to dicranostigma leptopodum injection and preparation method thereof. The dicranostigma leptopodum injection is prepared from a dicranostigma leptopodum extracting solution which is an active drug, and the dicranostigma leptopodum extracting solution is obtained by extracting through alcohol extraction and water precipitation, eluting and purifying through a resin column, and finally adding auxiliary materials. By the dicranostigma leptopodum injection, the blood glucose level of mice can be reduced remarkably, and further experiments show that by acupoint injection of the dicranostigma leptopodum injection, diabetic foot can be treated remarkably.

Description

technical field [0001] The invention relates to Lemahui injection and its preparation, in particular to Lemahui injection for treating diabetic foot and its preparation method. Background technique [0002] Diabetic foot is a serious complication of diabetes. It is one of the important causes of disability and even death of diabetic patients. It not only causes pain to patients, but also adds a huge economic burden to them. According to incomplete statistics, diabetic foot ulcers account for about 20%. [0003] Diabetic foot is prone to diabetic foot due to neuropathy that reduces the protective function of lower limbs, and macrovascular and microvascular lesions that cause arterial insufficiency and microcirculation disturbance. Among them, sensory neuropathy combined with excessive mechanical stress is the main initiating factor causing foot ulcers and infections. Inflammation and tissue damage are the result of some level of repeated stress on a specific area of ​​loss ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/80A61K9/08A61P3/10A61P17/02A61P25/20
CPCA61K9/0019A61K9/08A61K36/80A61K47/10A61K2236/333A61K2236/39A61K2236/55
Inventor 王景于洋张海丽回雪颖汪金宇刘大旭
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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