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Identification and application of lncRNA (long non-coding RNA) XLOC_000090 in lung cancer

A long-chain non-coding, non-small cell lung cancer technology, applied in the field of biomedicine, can solve problems such as unreported functions

Inactive Publication Date: 2017-01-04
TIANJIN MEDICAL UNIV CANCER INST & HOSPITAL
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Problems solved by technology

[0003] We screened 10 pairs of differentially expressed lncRNAs in lung cancer tissues and their corresponding normal lung tissues by gene chip technology, and found that the expression of XLOC_000090 in lung cancer tissues was significantly higher than that in normal lung tissues. Searching Pubmed and related databases found that XLOC_000090 The function in tumor has not been reported

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  • Identification and application of lncRNA (long non-coding RNA) XLOC_000090 in lung cancer
  • Identification and application of lncRNA (long non-coding RNA) XLOC_000090 in lung cancer
  • Identification and application of lncRNA (long non-coding RNA) XLOC_000090 in lung cancer

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Embodiment 1

[0018] 1 Materials and methods

[0019] 1.1 General information

[0020] From February 2008 to December 2010, 118 patients with non-small cell lung cancer and their corresponding normal lung tissues were collected from Tianjin Medical University Cancer Hospital (surgical resection pathologically confirmed non-small cell lung cancer, and all patients signed informed consent) book, complete follow-up data and a database of patient clinical records).

[0021] Inclusion criteria:

[0022] (1) Complete surgical resection (lobectomy or pneumonectomy plus hilar / mediastinal lymph node dissection);

[0023] (2) Pathologically confirmed non-small cell lung cancer.

[0024] Exclusion criteria:

[0025] (1) Preoperative chemotherapy or radiotherapy; (2) Positive surgical margin; (3) Non-small cell lung cancer patients who died within 1 month after surgery. Based on the inclusion and exclusion criteria, a total of 118 patients with NSCLC were included in this study. All patients were...

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Abstract

The invention relates to identification and application of lncRNA (long non-coding RNA) XLOC_000090 in lung cancer. A nucleotide sequence of an lncRNA XLOC_000090 expression gene is represented as SEQ ID No.1. An interrelation of XLOC_000090 expression and invasion, metastasis and prognosis of NSCLC (non-small cell lung cancer) is studied; differentially expressed lncRNA of 10 pairs of lung cancer tissue and normal lung tissue corresponding to the lung cancer tissue is screened out with a gene chip technology, and a result indicates that the expression of XLOC_000090 in the lung cancer is remarkably higher than that in the normal lung tissue. Therefore, the disclosed lncRNA XLOC_000090 expression gene can be used for detecting whether the lung cancer cells metastasize.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and relates to the relationship between the expression of XLOC_000090 and the invasion, metastasis and prognosis of NSCLC, more specifically, the identification and application of a long-chain non-coding RNA XLOC_000090 in tumors. Background technique [0002] Lung cancer is currently the malignant tumor with the highest morbidity and mortality in the world. Non-small cell lung cancer (NSCLC) accounts for about 80%-85% of lung cancers, and its 5-year survival rate is only about 15%. It is difficult to find out without specific diagnostic methods, and 70%-80% of patients have developed distant metastases at the time of diagnosis, losing the opportunity for surgery. How to effectively prevent and treat the recurrence and metastasis of non-small cell lung cancer after surgery has become an important problem to be solved urgently. A large number of studies have found that in the human genome, l...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68C12N15/113A61K48/00A61K31/7088A61P35/00
CPCA61K31/7088C12N15/113C12N2310/14C12Q1/6886C12Q2600/158C12Q2600/178C12N2320/30
Inventor 王长利张彬张华
Owner TIANJIN MEDICAL UNIV CANCER INST & HOSPITAL
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