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Forming system and method for three-dimensional layered vascular stent with bifurcated structure

A vascular stent, three-dimensional layered technology, applied in stents, instruments, prostheses, etc., can solve the problems of the three-layer structure of the difficult-to-stent blood vessel and the vascular bifurcation shape in the three-dimensional space of the difficult-to-stent, achieving a high degree of automation and a simple and reliable structure. , the effect of short cycle

Inactive Publication Date: 2019-12-13
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these traditional methods have obtained more successful vascular stents or stents with vascular networks, it is difficult to realize the three-dimensional structure of the stent and the shape of the vascular bifurcation in the current process of preparing a multi-layer vascular stent, but can achieve a certain three-dimensional bifurcation. It is difficult to realize the three-layer structure of the blood vessel by the process method of the flow channel structure

Method used

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  • Forming system and method for three-dimensional layered vascular stent with bifurcated structure
  • Forming system and method for three-dimensional layered vascular stent with bifurcated structure
  • Forming system and method for three-dimensional layered vascular stent with bifurcated structure

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Experimental program
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Effect test

Embodiment 1

[0054] see Figure 1 ~ Figure 3 , the forming system of the bifurcated three-dimensional layered vascular stent, including the frame (5), the mold system (Ⅰ), the hydrogel perfusion system (Ⅱ), the sacrificial material printing system (Ⅲ) and the computer control system (Ⅳ) , characterized in that: the mold system (I) is placed on the base of the frame (5); the hydrogel perfusion system (II) is movably installed on the frame (5), so that one of the syringe needles ( 34) Connecting a mold inlet conduit (24) of the mold system (I); the sacrificial material printing system (III) is installed on the frame (5) and connected to drive the hydrogel perfusion system (II) to move; The computer control system (IV) is electrically connected to control the three-dimensional movement of a three-dimensional motion mechanism (31) in the sacrificial material printing system (III) and a syringe piston cylinder B (33) to extrude the sacrificial material.

Embodiment 2

[0056] This embodiment is basically the same as Embodiment 1, and the special features are as follows:

[0057] Described mold system (I) comprises mold 1 (11), mold 2 (12), mold 3 (13), mold 4 (14) and mold 5 (15); The entrance and the outlet of mold 1 (11) two ends are respectively Connected with inlet conduit (24) and outlet conduit (25); in the process of perfusion hydrogel, mold 2 (12), mold 3 (13), mold 4 (14) and mold 5 (15) convex or concave The lower path matches with the concave path of the mold 1 (11) respectively.

[0058] The hydrogel perfusion system (II) consists of micropump controller A (21), micropump actuator A (22), syringe piston barrel A (23), inlet conduit (24) and outlet conduit (25) Composition: Syringe piston barrel A (23) is installed on the micropump actuator A (22) and is fixed by the set bolt, and the micropump actuator A (22) is driven by the micropump controller A (21). Syringe piston cylinder body A (23) carries out the extruding of hydrogel,...

Embodiment 3

[0062] The forming method of the bifurcated three-dimensional layered vascular stent adopts the above-mentioned system for operation, and the operation steps are as follows:

[0063] 1) Forming the lower half of the outer layer of the vascular stent: combining mold 1 and mold 2 so that the axes of the respective pipes coincide. After the mold is closed, inject the hydrogel solution through the inlet conduit on one side of the mold 1 through the syringe needle until the solution flows out from the outlet conduit on the other side of the mold 1. After the hydrogel solution gels, remove the mold 2 , the lower half layer structure of the outer layer of the stent can be obtained;

[0064] 2) Forming the lower half of the inner layer of the vascular stent: combining the mold 1 and the mold 3 so that the axes of the respective pipes coincide. After closing the mold, inject the hydrogel solution through the inlet conduit on one side of the mold 1 through the syringe needle until the ...

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Abstract

The invention discloses a forming system and method for three-dimensional layered vascular stents with bifurcated structures. The system comprises a mold system, a hydrogel perfusion system, a sacrificial material printing system and a computer control system; the mold system is manufactured through a 3D printing technology; the hydrogel perfusion system is combined with the mold system and achieves the perfusion of a hydrogel solution by being driven by a micro pump, the sacrificial material printing system drives the micro pump to move according to a designated route through a three-dimensional motion mechanism to achieve printing of a sacrificial material; the computer control system drives the three-dimensional motion mechanism to move. According to the forming system and method for the three-dimensional layered vascular stents with the bifurcated structures, on the basis of a hydrogel perfusion principle and a sacrificial material principle, molds are manufactured through the 3D printing technology, the mode of perfusing hydrogel into the molds is adopted, and layer-by-layer preparation of the vascular stents is conducted; by means of the sacrificial material, hollow structures of the vascular stents are achieved by means of a method of conducting addition first and then conducting sacrificing, and the three-dimensional layered vascular stents with the bifurcated structures are formed finally.

Description

technical field [0001] The invention relates to a forming system and method for a three-dimensional layered vascular stent with a bifurcated structure, which can realize a bifurcated vascular stent in a three-dimensional space with a layered structure, and is applied in the technical fields of mechanical manufacturing and biomanufacturing. Background technique [0002] In recent years, cardiovascular disease has gradually become an important factor that threatens health. Due to the lack of suitable autologous blood vessels, a large number of patients need artificial blood vessel transplantation every year. The construction of functional tissue vascular scaffolds has broad application prospects. [0003] The inner diameter of blood vessels in the human body ranges from 5 microns to 25 mm, and the walls of larger blood vessels have an obvious three-layer structure: intima, media and adventitia. The intima is a single layer of endothelial cells attached to the basement membran...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/52A61L27/50A61L27/18A61F2/82B29C67/24B33Y70/00B33Y80/00G06F17/50
CPCA61F2/82A61F2240/001A61L27/18A61L27/507A61L27/52A61L2430/22B29C67/24B33Y70/00B33Y80/00G06F30/13C08L71/02
Inventor 刘媛媛蒋维健谢明亮胡庆夕
Owner SHANGHAI UNIV
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