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An experimental device for interstitial flow cell mechanobiology

An experimental device and biological technology, applied in the field of interstitial flow cell mechanobiology experimental device, can solve the problems of lack of interstitial flow simulation device, etc., and achieve the effect of strong operability, simple structure and low cost

Active Publication Date: 2018-04-17
SICHUAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently a lack of applicable gap flow simulations on how to apply controllable gap flow shear loading to the same or different types of cells, how to better study the response of cells to gap flow shear stress and related molecular mechanisms device

Method used

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  • An experimental device for interstitial flow cell mechanobiology
  • An experimental device for interstitial flow cell mechanobiology
  • An experimental device for interstitial flow cell mechanobiology

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Embodiment Construction

[0023] The present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments, wherein the schematic embodiments and descriptions are only used to explain the present invention, but are not intended to limit the present invention.

[0024] Such as Figure 1-Figure 5 As shown, the interstitial flow cell mechanobiology experimental device described in this specific embodiment includes an experimental device body 1, and the experimental device body 1 includes a platen 2, and the left and right sides of the surface of the platen 2 are correspondingly arranged There are left through holes 21 and right through holes 22. Four table screw holes are provided at the four corners of the surface of the table plate 2. Four table bolts 5 are screwed in the four table screw holes. The bottom ends of the table bolts 5 are provided with supporting foot caps. ;

[0025] The left through hole 21 and the right through hole 22 of the platen ...

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Abstract

The invention specifically relates to a cellular mechanobiological experimental apparatus for interstitial flow, belonging to the technical field of cellular mechanobiology. The experimental apparatus comprises a body; the body comprises a platen; the left and right sides of the surface of the platen are respectively provided with a left through hole and a right through hole; the four corners of the surface of the platen are provided with four table-top screw holes; four table-top bolts are screwed in the four table-top screw holes; the bottom ends of the table-top bolts are provided with supporting leg caps; and the left through hole and the right through hole in the platen are respectively provided with an experimental box A and an experimental box B. The cellular mechanobiological experimental apparatus is simple in structure, low in cost and good in operability. According to the invention, interstitial flow shearing force with different strength are loaded via a syringe pump so as to research response of cells in a transparent cup to simulated interstitial flow shearing force, so interstitial flow in the tissue of the human body is simulated; and controllable interstitial flow shearing force loads are applied to same or different cells so as to research response of cells to interstitial flow shearing force and related molecular mechanisms, which represents the novel technological development trend in the field of cellular mechanobiology.

Description

【Technical field】 [0001] The invention relates to the technical field of cell mechanobiology, in particular to an experimental device for interstitial flow cell mechanobiology. 【Background technique】 [0002] Cell biology takes cells as the research object, and studies the structure and function of cells and organelles, the life history of cells and various life discipline of activity. Cell mechanobiology mainly explores the influence of mechanical environment (stimulation) on cells through the organic combination of cell biology and mechanical principles, and studies the mechanical signal perception and response mechanism of cells and their participation in mechanical and biological processes of the body, such as growth. , reconstruction, adaptive change and repair, so as to develop new technologies with curative effect or diagnostic significance, promote the development of biomedical basic and clinical research, and promote human health. [0003] Intracellular fluid is t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12M1/00
CPCC12M35/04
Inventor 曾烨刘肖珩
Owner SICHUAN UNIV
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