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Cellular mechanobiological experimental apparatus for interstitial flow

An experimental device and biological technology, applied in the field of interstitial flow cell mechanobiology experimental device, can solve the problems of lack of interstitial flow simulation device, etc., and achieve the effect of strong operability, low cost and simple structure

Active Publication Date: 2016-11-16
SICHUAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is currently a lack of applicable gap flow simulations on how to apply controllable gap flow shear loading to the same or different types of cells, how to better study the response of cells to gap flow shear stress and related molecular mechanisms device

Method used

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  • Cellular mechanobiological experimental apparatus for interstitial flow
  • Cellular mechanobiological experimental apparatus for interstitial flow
  • Cellular mechanobiological experimental apparatus for interstitial flow

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Embodiment Construction

[0023] Hereinafter, the present invention will be described in detail with reference to the drawings and specific embodiments. The illustrative embodiments and descriptions are only used to explain the present invention, but are not intended to limit the present invention.

[0024] Such as Figure 1-Figure 5 As shown, the interstitial flow cell mechanics biology experimental device described in this specific embodiment includes an experimental device body 1, the experimental device body 1 includes a platform 2, and the surface of the platform 2 is provided on the left and right sides correspondingly There are left through holes 21 and right through holes 22. The four corners of the surface of the table 2 are provided with four countertop screw holes, four countertop bolts 5 are screwed into the four countertop screw holes, and the bottom end of the countertop bolt 5 is provided with a support foot cap ;

[0025] The left through hole 21 and the right through hole 22 of the platen ...

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Abstract

The invention specifically relates to a cellular mechanobiological experimental apparatus for interstitial flow, belonging to the technical field of cellular mechanobiology. The experimental apparatus comprises a body; the body comprises a platen; the left and right sides of the surface of the platen are respectively provided with a left through hole and a right through hole; the four corners of the surface of the platen are provided with four table-top screw holes; four table-top bolts are screwed in the four table-top screw holes; the bottom ends of the table-top bolts are provided with supporting leg caps; and the left through hole and the right through hole in the platen are respectively provided with an experimental box A and an experimental box B. The cellular mechanobiological experimental apparatus is simple in structure, low in cost and good in operability. According to the invention, interstitial flow shearing force with different strength are loaded via a syringe pump so as to research response of cells in a transparent cup to simulated interstitial flow shearing force, so interstitial flow in the tissue of the human body is simulated; and controllable interstitial flow shearing force loads are applied to same or different cells so as to research response of cells to interstitial flow shearing force and related molecular mechanisms, which represents the novel technological development trend in the field of cellular mechanobiology.

Description

【Technical Field】 [0001] The invention relates to the technical field of cell mechanics biology, in particular to an interstitial flow cell mechanics biology experimental device. 【Background technique】 [0002] Cell biology is the research object of cells, from the overall level of cells, sub-microscopic level, molecular level, etc., to study the structure and function of cells and organelles, cell life history and various life from a dynamic perspective. The discipline of regular activity. Cell mechanics biology mainly through the organic combination of cell biology and mechanics principles and methods, to explore the impact of the mechanical environment (stimulus) on cells, to study the mechanical signal perception and response mechanism of cells and their participation in the body's mechanical and biological processes such as growth , Reconstruction, adaptive change and repair and other molecular mechanisms, so as to develop curative or diagnostically significant new technolo...

Claims

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Application Information

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IPC IPC(8): C12M1/00
CPCC12M35/04
Inventor 曾烨刘肖珩
Owner SICHUAN UNIV
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