Protecting and repairing material for post-injury uterine cavity and preparation method thereof
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A technology for repairing materials and uterine cavity, applied in the field of medicine, can solve problems such as inability to evenly coat the damaged surface of the uterine cavity, weak bonding of the damaged surface, affecting clinical efficacy, etc. Smooth healing effect
Inactive Publication Date: 2016-11-09
杭州语奥生物科技有限公司
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[0004] As we all know, the environment of the uterine cavity is a closed environment. Due to the effect of the smooth muscle of the uterine body, it is in a closed application state, which leads to the fact that ordinary gel materials cannot be evenly applied to the dam...
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Embodiment 1
[0030] 1) Formula of protective and repairing materials after uterine cavity injury: in mass fraction, kg / kg, %
[0031]
[0032] 2) Preparation method of protective and repairing materials after uterine cavity injury:
[0033] A. In an ice bath at 0°C, mix the block copolymer of polyoxyethylene polyoxypropylene ether and sodium alginate, add pure water to swell, and dissolve into a solution;
[0034] B, add polyhydric alcohol in the solution that A obtains, add glycerol drop by drop under stirring, obtain mixed solution;
[0035] C. Degas the mixed solution in a vacuum at -20kPa in an ice bath at 0°C until there are no bubbles in the mixed solution to obtain a transparent and clear solution;
[0036] D. Filter the transparent and clear solution obtained in C with a 0.22-0.45 μm microporous membrane, maintain a low temperature of 0-5°C and fill it in a container, which includes one of a cartridge, a vial, and a prefilled syringe One or several types, the specifications an...
Embodiment 2
[0037] 1) Formula of protective and repairing materials after uterine cavity injury: in mass fraction, kg / kg, %
[0038]
[0039] 2) The preparation method of the protective and repairing material after uterine cavity injury is the same as that in Example 1.
Embodiment 3
[0041] 1) Formula of protective and repairing materials after uterine cavity injury: in mass fraction, kg / kg, %
[0042]
[0043] 2) The preparation method of the protective and repairing material after uterine cavity injury is the same as that in Example 1.
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Abstract
The invention relates to a protecting and repairing material for a post-injury uterine cavity and a preparation method thereof. The protecting and repairing material for the post-injury uterine cavity, provided by the invention, is prepared from the following raw materials in percentage by weight (based on total weight of the raw materials): 5% to 55% of polyoxyethylene-polyoxypropylene ether block copolymer, 0.1% to 3% of sodium alginate, 1% to 25% of glycerine, 5% to 15% of polyalcohol and the balance of pure water. The protecting and repairing material for the post-injury uterine cavity, provided by the invention, is unique in performance and convenient in use and is a gel material which is good in biocompatibility and is safe, non-toxic and nonirritant; due to unique temperature response performance, the protecting and repairing material can be used for rapidly and comprehensively covering a uterine wound surface in a liquid fluid state and forming a stable gel state under the condition of body temperature, so as to effectively isolate the wound surface and effectively protect the wound surface of surgical operation. The gel material has an extremely high application value in uterine cavity injury protection.
Description
technical field [0001] The invention relates to a material for protecting and repairing uterine cavity after injury and a preparation method thereof, belonging to the field of medicine. Background technique [0002] The uterine cavity is a special environment, and uterine cavity injury has brought more impacts on women's reproductive health and physical health. Compared with intrauterine adhesions, infertility, and accessory injuries caused by uterine cavity injuries, more and more medical workers have attracted the attention of medical workers. The prevention and treatment of uterine cavity injuries has become a category of prevention and treatment of uterine cavity injuries. Inevitable process of surgery. [0003] At present, with regard to the prevention of uterine cavity injury, there are many measures such as gel material or contraceptive ring in clinical practice. Among them, the more effective one is to fill the uterine cavity with anti-adhesion gel material to preve...
Claims
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