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A molecular marker related to nasopharyngeal carcinoma and its application

A nasopharyngeal cancer, molecular technology, applied in the fields of molecular biology and oncology

Active Publication Date: 2018-11-02
THE FIRST PEOPLES HOSPITAL OF FOSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

LncRNA has been shown to be involved in the occurrence and development of many tumors, however, there are only a few reports on nasopharyngeal carcinoma

Method used

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  • A molecular marker related to nasopharyngeal carcinoma and its application
  • A molecular marker related to nasopharyngeal carcinoma and its application
  • A molecular marker related to nasopharyngeal carcinoma and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] 1. Screening of lncRNA molecules related to nasopharyngeal carcinoma

[0046] 1. Case collection

[0047] A total of 19 patients who were hospitalized in the Nasopharyngeal Radiotherapy Department of the First People's Hospital of Foshan City, Guangdong Province from February 2014 to August 2014 were collected. All patients did not undergo radiotherapy and chemotherapy before operation, other systemic medical history was excluded, and the functions of vital organs were within the normal range. The age ranged from 21 to 61 years, with a median age of 45 years. The clinical data of the samples are shown in Table 1-1, and 6 cases were randomly selected. Used for microarray research, and the remaining 13 cases were used for further verification. Informed consent of the patients was obtained for the collection of specimens in the experiment, and the authorization was obtained from the Ethics Committee of the First People's Hospital of Foshan City, Guangdong Province.

[00...

Embodiment 2

[0126] In order to further verify that lncRNA: ENST00000513572 can be used as a molecular marker or target of nasopharyngeal carcinoma, the inventors further expanded the number of samples and conducted further experiments.

[0127] 1. Case collection

[0128] From December 2012 to August 2015, the peripheral blood samples of nasopharyngeal cancer patients hospitalized in the Department of Head and Neck Radiotherapy, Foshan First People's Hospital were collected as the sample bank of the experimental group, while the non-cancer peripheral blood sample banks of the control group were collected from From September 2015 to November 2015, patients in the Health Care Department of Foshan First People's Hospital and inpatients in the Department of Otorhinolaryngology. The specimen collection in the trial obtained the informed consent of the patients and was authorized by the Ethics Committee of the First People's Hospital of Foshan City, Guangdong Province. All patients with nasopha...

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Abstract

The invention discloses a molecular marker related to NPC (nasopharyngeal carcinoma) and an application of the molecular marker. The marker is an lncRNA (long noncoding RNA) molecule, is named ENST00000513572, and the nucleotide sequence of the marker is shown as SEQ ID NO.1. The expression quantity of ENST00000513572 in NPC tissue is obviously higher than that of ENST00000513572 in adjacent tissue, the lncRNA molecule can be taken as an NPC molecular marker or target to be applied to clinical early diagnosis, prognosis or targeted therapy of the NPC, is beneficial to further explanation of occurrence and development mechanisms of the NPC, signaling pathways and the like and has great application prospect and theoretical value.

Description

technical field [0001] The invention belongs to the fields of molecular biology and oncology, and specifically relates to a nasopharyngeal carcinoma-related molecular marker lncRNA: ENST00000513572 and its application in clinical diagnosis, treatment, prognosis assessment or scientific research of nasopharyngeal carcinoma. Background technique [0002] Nasopharyngeal carcinoma (nasopharyngeal carcinoma, NPC) is one of the most common malignant tumors in southern China. It has the highest incidence rate in southern China, especially in Guangdong Province, ranking first in the world, so it is also called "Guangdong cancer". NPC is sensitive to radiation, and radiotherapy is the first choice, and its prognosis varies greatly depending on the stage of the disease. Radiotherapy alone is effective for stage I and stage II patients, and the 10-year disease-related survival rate, recurrence-free survival rate, and distant metastasis-free survival rate are all high. However, the ons...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N15/113C12Q1/6886
CPCC12N15/113C12N2310/10C12Q1/6886C12Q2600/118C12Q2600/158C12Q2600/178
Inventor 王跃建罗微夏世同唐隽陈伟雄
Owner THE FIRST PEOPLES HOSPITAL OF FOSHAN
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