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Chitosan bleeding stopping and pain relieving powder and preparation method thereof

The technology of chitosan and analgesic powder is applied in the field of chitosan hemostatic and analgesic powder and its preparation field, which can solve the problems of insignificant analgesic effect, complicated organic reagents and high overall cost, improve the hemostatic and analgesic effect and simplify the treatment process. , increase the effect of pain relief

Inactive Publication Date: 2016-10-12
HENAN TUOREN BEST MEDICAL DEVICE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The emulsification and cross-linking method is often used in the preparation process, and the use of organic reagents is complicated. For the later sample processing process, the process is complicated and easy to cause environmental pollution.
The overall cost is high and expensive, but the hemostatic effect is similar, and the analgesic effect is not obvious or has no such effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Dissolve 2 g of sodium alginate and 0.5 g of carboxymethyl chitosan into 60 mL and 50 mL of distilled water, respectively. Add the carboxymethyl chitosan solution into the sodium alginate solution, and stir and mix thoroughly. Then add 40 mL of 1.0 g of calcium chloride solution, stir well, cross-link to form a hydrogel system, let it stand for precipitation, and discard the supernatant. Wash 3 times with distilled water until the pH is 5.0-7.0, dry in vacuum, grind, sieve, and make powder. Add appropriate amount of lidocaine hydrochloride 0.1g and thrombin 0.4mg to the powdery solid, mix well, and grind into powder , irradiated and sterilized, and packaged as a hemostatic and pain-relieving powder.

[0018] In rat femoral artery and liver hemorrhage models, the hemostatic and analgesic powder produced was significantly better than Yunnan Baiyao and other similar products. The mouse tail flick test proved that the analgesic effect is good.

Embodiment 2

[0020] Dissolve 5 g of sodium alginate and 1 g of carboxymethyl chitosan into 150 mL and 100 mL of distilled water, respectively. Add the carboxymethyl chitosan solution into the sodium alginate solution, and stir and mix thoroughly. Then add 80mL of 2.5g calcium chloride solution, stir well, cross-link to form a hydrogel system, let it stand for precipitation, and discard the supernatant. Wash with distilled water three times until the pH is 5.0-7.0, dry in vacuum, grind, sieve, and powder. An appropriate amount of lidocaine hydrochloride (0.1%) and 1 mg of thrombin are added to the powdery solid, mixed evenly, irradiated and sterilized and packaged to become hemostatic and pain-relieving powder.

[0021] In rat femoral artery and liver hemorrhage models, the hemostatic and analgesic powder produced was significantly better than Yunnan Baiyao and other similar products. The mouse tail flick test proved that the analgesic effect is good.

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Abstract

The invention relates to chitosan bleeding stopping and pain relieving powder and a preparation method thereof. The chitosan bleeding stopping and pain relieving powder is prepared from the following components in parts by weight: 0.1 to 10 parts of carboxymethyl chitosan, 0.1 to 10 parts of sodium alginate, 0.0004 part of thrombin and 0.1 to 2 parts of lidocaine hydrochloride. The components are cross-linked by calcium chloride, washed, dried and ground into powder. The chitosan bleeding stopping and pain relieving powder and the preparation method thereof have the advantages that the preparation method is simple and green; the production cost is low; the water-absorption swelling rate is high, the convenience in use is realized, and the bleeding stopping and pain relieving effects are good.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a chitosan hemostatic and pain-relieving powder and a preparation method thereof. Background technique [0002] Hemorrhage is the first cause of death in war injuries and the second cause of death in trauma. Hemorrhage is also the main cause of death in the operating room of trauma patients. Rapid and effective control of hemorrhage can significantly reduce the death caused by excessive bleeding; Timely and rapid analgesia can significantly reduce the pain caused by pain to injured patients. Hemostasis can reduce blood loss during surgery, keep the surgical field clear, prevent important tissue damage, ensure surgical safety and postoperative wound healing, reduce infection, shorten operation time, It is of great significance to the prognosis of patients; pain is a protective reaction produced by the body after being subjected to noxious stimuli, and is o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00A61L24/08A61L24/10
CPCA61L24/0015A61L24/08A61L24/108A61L2300/204A61L2300/254A61L2300/402A61L2300/418C08L5/08C08L5/04C08L89/00
Inventor 崔景强徐鹏乐牛利卫张洪亮
Owner HENAN TUOREN BEST MEDICAL DEVICE CO LTD
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