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Kit for detecting medication effects of clozapine and risperidone by virtue of rs4680 polymorphism

A kit and the technology of clozapine, applied in the genetic field, can solve problems such as undiscovered

Inactive Publication Date: 2016-09-07
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Retrieval of the existing literature did not find relevant reports that the fourth exon SNP rs4680 of the COMT gene of the present invention is a molecular marker of clozapine

Method used

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  • Kit for detecting medication effects of clozapine and risperidone by virtue of rs4680 polymorphism
  • Kit for detecting medication effects of clozapine and risperidone by virtue of rs4680 polymorphism
  • Kit for detecting medication effects of clozapine and risperidone by virtue of rs4680 polymorphism

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Embodiment Construction

[0033] Below in conjunction with specific embodiment, further illustrate the present invention. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. The experimental method that does not indicate specific conditions in the following examples, usually according to conventional conditions, such as the molecular cloning of people such as Sambrook: the conditions described in the laboratory manual (New York: Cold Spring Harbor Laboratory Press, 1989), or according to the manufacturer suggested conditions.

[0034] The invention relates to a method for detecting the single nucleotide polymorphism of the fourth exon SNP rs4680 of the COMT gene, as well as related isolated nucleic acids and primers. Through association analysis, the present invention unexpectedly discovered that the fourth exon SNP rs4680 of the COMT gene (ID: 1312) can be used as a molecular marker for clozapi...

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Abstract

The invention relates to a kit for detecting medication effects of clozapine and risperidone by virtue of rs4680 polymorphism, and belongs to the field of gene technology. The invention relates to separated nucleotide which contains a single-nucleotide polymorphism site, wherein the sequence of the nucleotide is as shown in SEQ ID NO: 1; the single-nucleotide polymorphism site is on the 854th position; and rs4680 is as shown from G to A. The invention relates to a method for detecting the nucleotide, wherein the method comprises the following steps: 1, detecting the nucleotide which has the sequence as shown in SEQ ID NO: 1 and is located on the 854th position; and 2, by virtue of a Taqman-MGB typing method, detecting whether single-nucleotide polymorphism exists on the 854th position or not. The kit disclosed by the invention lays a foundation for researching a relation between COMT (catechol-O-methyl transferase) gene polymorphism in China's people and clinical medication safety and provides a theoretical basis for the individualization of clinical medication; and meanwhile, the kit also provides a guidance basis to new drug research and development on the basis of pharmacogenomics concept.

Description

technical field [0001] The invention belongs to the field of gene technology, and in particular relates to a kit for detecting the drug effects of clozapine and risperidone by using rs4680 polymorphism. Background technique [0002] The chemical name of Clozapine is 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine, molecular formula C18H19ClN4 . Clozapine is the most common drug for the treatment of mental illness in China. It is not only effective for positive symptoms of psychosis, but also for negative symptoms. It is suitable for all subtypes of acute and chronic schizophrenia, and has a good effect on hallucination, delusional and youthful schizophrenia. It may also reduce affective symptoms (eg, depression, guilt, anxiety) associated with schizophrenia. The chemical name of Risperidone is 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidine]ethyl]-6,7, 8,9-Tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one, with the molecular formula C23H27FN4O2...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68C12N15/11
CPCC12Q1/6827C12Q1/686C12Q1/6883C12Q2600/106C12Q2600/156C12Q2563/107C12Q2545/114C12Q2531/113C12Q2561/101
Inventor 秦胜营周伟徐青青施烨贺林
Owner SHANGHAI JIAO TONG UNIV
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