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Single-molecule gene sequencer

A gene sequencer and gene sequencing technology, applied in the directions of instruments, analytical materials, measuring devices, etc., can solve the problems of high cost and low efficiency, and achieve the effect of reducing the cost of sequencing and simple and convenient operation.

Active Publication Date: 2016-08-17
GENEMIND BIOSCIENCES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a single-molecule gene sequencer to solve the problems of low efficiency and high cost in the prior art

Method used

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Embodiment Construction

[0082] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the drawings in the embodiments of the present invention.

[0083] From Figures 1 to 16 It can be seen that the single-molecule gene sequencer of the present invention includes a machine base 1, and the machine base 1 is provided with a clamping platform 2, a reagent storage device 3, a fluid control device 4 and a mobile platform 5; the clamping platform 2 A gene sequencing chip 6 is arranged on it; the reagent storage device 3 is used to store gene sequencing reagents; the fluid control device 4 is used to pump the gene sequencing reagents from the reagent storage device 3 to the gene sequencing chip 6; the base 1 is also provided with a total reflection microscope 7, the mobile platform 5 is located below the total reflection microscope 7, the clamping platform 2 is located on the mobile platform 5, and the mobile platform 5 is us...

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Abstract

The invention discloses a single-molecule gene sequencer, and belongs to technical schemes of the field of gene sequencing. The single-molecule gene sequencer comprises a base, wherein a clamping platform, a reagent storing device, a fluid control device, a moving platform and a total-reflection microscope are arranged on the base; a gene sequencing chip is arranged on the clamping platform; the reagent storing device is used for storing a gene sequencing reagent; the fluid control device is used for pumping the gene sequencing reagent into the gene sequencing chip from the reagent storing device; the moving platform is used for driving the clamping platform to move to or away from the part below the a total-reflection microscope; the total-reflection microscope is used for detecting gene sequences of samples in the gene sequencing chip. The scheme has no library development flow or PCR, is simple and convenient to operate and low in sequencing cost, and is a diagnosis and treatment method very applicable to clinical application.

Description

technical field [0001] The invention relates to a gene sequencing device, in particular to a single-molecule gene sequencer. Background technique [0002] With the continuous development of gene sequencing technology, second-generation high-throughput sequencing technology has been widely used in various research fields, but with the promotion of applications, the shortcomings of next-generation sequencing have become increasingly prominent. For example, library construction is required, and the process is not only complicated but also time-consuming; PCR amplification is required, which is prone to bias, resulting in distortion of the original gene ratio; sequencing read length is short, and it is difficult for bioinformatics such as subsequent sequence splicing and assembly. Analysis is difficult. Therefore, the third-generation single-molecule sequencing technology emerged as the times require. It adopts single-molecule reading technology, which has higher sensitivity an...

Claims

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Application Information

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IPC IPC(8): C12M1/34C12M1/36
CPCC12Q1/6869C12Q2565/619G01N2021/6471G01N21/6458G01N2201/06113G02B21/06G02B21/16G02B21/245G01N21/648C12Q2565/601C12M1/34B01L3/502B01L9/50B01L2200/025B01L2200/10B01L2300/0609B01L2300/0654B01L2300/0672B01L2300/18G01N21/6428G01N2201/068
Inventor 颜钦姜泽飞郑焦吴平周志良葛良进
Owner GENEMIND BIOSCIENCES CO LTD
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