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Polypeptide with binding affinity to hpv18 E7 protein and application thereof

A kind of affinity and protein technology, applied in the field of bioengineering, can solve problems such as unsatisfactory results

Active Publication Date: 2019-08-20
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although in the past 60 years, scholars at home and abroad have conducted a lot of research, and cervical cancer prevention vaccines have been marketed, but due to the coexistence of many factors, the current clinical treatment of cervical cancer is still not satisfactory.

Method used

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  • Polypeptide with binding affinity to hpv18 E7 protein and application thereof
  • Polypeptide with binding affinity to hpv18 E7 protein and application thereof
  • Polypeptide with binding affinity to hpv18 E7 protein and application thereof

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Embodiment Construction

[0075] The present invention is specifically described below by the embodiment, only for further illustrating the present invention, can not be interpreted as the limitation of protection scope of the present invention, the technical engineer of this field can make some non-essential improvements and improvements to the present invention according to the content of the above-mentioned invention Adjustment.

[0076] As used herein, the "polypeptide with binding affinity for HPV18 E7" refers to a polypeptide obtained after 12-20 amino acid mutations using the amino acid sequence of the Z segment of staphylococcal protein A as the backbone, and the polypeptide can specifically Binds HPV18 E7 with little or no non-specific binding.

[0077] As used herein, the "polypeptide of the present invention", "polypeptide with binding affinity to HPV18 E7", "HPV18E7 binding polypeptide", "Z HPV18E7 affibody peptide", "Z HPV18E7 affibody", "Z HPV18E7”、"affibody protein", "affibody recom...

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Abstract

The invention discloses a polypeptide with binding affinity for HPV18 E7 protein and application thereof. The invention is the first to reveal the polypeptide with binding affinity for HPV18 E7 protein. The invention also provides the diagnosis or treatment application of the polypeptide used as a medicament or a molecular targeted agent.

Description

technical field [0001] The invention belongs to the field of bioengineering, in particular to a polypeptide with binding affinity to HPV18E7 (E7 protein of human papillomavirus type 18) and its application. Background technique [0002] Cervical cancer is a major disease that threatens human health and life. The incidence of cancer in women ranks second, second only to breast cancer. It is more common in developing countries. In recent years, it has even become younger. In my country, there are approximately 131,500 new cases of cervical cancer each year, accounting for 1 / 7 of the world's total. The incidence and mortality of cervical cancer rank second in the world. Although in the past 60 years, scholars at home and abroad have conducted a lot of research, and cervical cancer prevention vaccines have been launched, but due to the coexistence of many factors, the current clinical treatment of cervical cancer is still not satisfactory. [0003] Human papillomavirus (Human P...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K14/31C12N15/31C12P21/02A61K38/16A61P35/00A61P31/20G01N33/68G01N33/574G01N33/569
Inventor 张丽芳王乐丹薛向阳朱珊丽蒋朋飞李文姝陈俊
Owner WENZHOU MEDICAL UNIV
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