Chromatographic tank for extracting artemisinin and its high-efficiency pressurized chromatography method

Abstract

The invention discloses a chromatography tank for artemisinin extraction and an efficient pressurized chromatography method thereof and belongs to the field of artemisinin extraction equipment and methods. The chromatography tank comprises a tank body, a gasoline inflow pipe, an extracting solution inflow pipe and an eluent inflow pipe. A feeding gate is arranged on the top of the tank body. A discharging door is arranged on one side of the lower portion of the tank body. A material supporting screen is arranged on the lower portion in the tank body. A compressed air inlet and an air blowoff valve are arranged on the top of the tank body. The bottom of the tank body is connected with a main discharge pipe, a main valve is arranged on the main discharge pipe, the lower end of the main discharge pipe is communicated with an agent checking transfer tank, and the transfer tank is connected with multiple classification discharge pipes. The efficient pressurized chromatography method includes the steps of A, material preparation; B, whole column liquid level reducing; C, column feeding; D, first pressurizing extracting solution liquid level reducing; E, second pressurizing eluent liquid level reducing; F, eluting without an agent; G, eluting with the agent; H, third pressurizing eluent liquid level reducing. The agent content of eluent can be precisely detected, washing liquor is recovered in a classified mode, the utilization rate of the washing liquor containing the agent is increased, and the production period is shortened.

Description

technical field [0001] The invention relates to an artemisinin extraction equipment and extraction process, in particular to a chromatography tank for artemisinin extraction and a high-efficiency pressurized chromatography method thereof. Background technique [0002] Artemisia annua: the whole herb of Artemisia annua L. of Compositae, which is a high-efficiency and quick-acting antimalarial drug. It acts on the red blood cell stage of Plasmodium, is suitable for vivax malaria and falciparum malaria, and is especially effective in rescuing cerebral malaria. Its antipyretic time and malaria parasite negative time are shorter than chloroquine. Plasmodium that is resistant to chloroquine is also effective in using this product. The method of extracting artemisinin from Artemisia annua is based on the extraction principle, mainly including ether extraction method and solvent oil extraction method. Its active ingredient (artemisinin) is mainly separated by organic solvent extr...

AI Technical Summary

Problems solved by technology

It is an important separation step through silica gel column chromatography. The original chromatography tank production process does not have pressurized chromatography, and the production time is long. That is, the production cycle of completing the chromatography of a column of silica gel column and the recovery of silica gel particles is 24- 30 hours, low production efficiency

And because the chromatographic equipment is continuously loaded and eluted, the effective drug content in the eluent discharged after the eluent is eluted from the silica gel column is a dynamic process, that is, no drug → a small amount of drug → a large amount The gradual change process of drug → small amount of drug → no drug, the existing equipment cannot accurately grasp the change node of the lotion at any time

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