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Calcium carbonate D3 granules and preparation method thereof

A technology of calcium carbonate and granules, which is applied in the direction of pharmaceutical formulations, active ingredients of aluminum/calcium/magnesium, and medical preparations of non-active ingredients, etc. The stability of D3 granules is not good, and the curative effect of calcium carbonate D3 granules is unstable, etc., to achieve the effect of stable and controllable product quality, low cost, and not easy to deteriorate.

Active Publication Date: 2016-05-04
HAINAN HULUWA PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The calcium carbonate D3 granule that existing method prepares generally has two problems: (1) because vitamin D3 consumption is few, the content uniformity of vitamin D3 in the granule preparation is poor, can make the curative effect of calcium carbonate D3 granule unstable; (2) The stability of calcium carbonate D3 particles is not good, especially vitamin D3 is not stable enough, it is easy to deteriorate, and it is not easy to store for a long time
Yet the calcium carbonate D3 particle that this method prepares still does not overcome the bad defective of uniformity and stability

Method used

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  • Calcium carbonate D3 granules and preparation method thereof
  • Calcium carbonate D3 granules and preparation method thereof
  • Calcium carbonate D3 granules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028]

[0029] Steps:

[0030] (1) Dissolve hypromellose in 1 / 2 of the prescription volume of 75% ethanol aqueous solution, then add 1 / 2 of the prescription volume of calcium carbonate and mix evenly, set aside.

[0031] (2) Pour the remaining calcium carbonate, maltodextrin, glucose and sodium citrate into a mixer and mix, then add the raw materials in step (1) and mix evenly to obtain a mixture;

[0032] (3) Granulation: dissolving vitamin D3 and xanthan gum in the remaining 75% ethanol to prepare a binder. Mix with the above mixture to make a soft material, dry at 50°C for 3 hours after granulation, granulate, and pack separately to obtain calcium carbonate D3 granules.

Embodiment 2

[0034]

[0035] Steps:

[0036] (1) Dissolve hypromellose in 1 / 2 of the prescription volume of 75% ethanol solution, then add 1 / 2 of the prescription volume of calcium carbonate and mix evenly, set aside.

[0037] (2) Pour the remaining calcium carbonate, maltodextrin, glucose and sodium citrate into a mixer and mix, then add the raw materials in step (1) and mix evenly to obtain a mixture;

[0038] (3) Granulation: dissolving vitamin D3 and xanthan gum in the remaining 75% ethanol to prepare a binder. Mix with the above mixture to make a soft material, dry at 40°C for 4 hours after granulation, granulate, and pack separately to obtain calcium carbonate D3 granules.

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Abstract

The invention discloses calcium carbonate D3 granules and a preparation method thereof. The calcium carbonate D3 granules are prepared from the following raw materials in parts by weight: 12kg to 18kg of calcium carbonate, 0.01kg to 0.05kg of vitamin D3, 1kg to 5kg of maltodextrin, 1kg to 5kg of glucose, 0.1kg to 0.5kg of sodium citrate, 0.01kg to 0.05kg of xanthan gum, 0.1kg to 0.5kg of hydroxypropyl methylcellulose and 5kg to 10kg of 75 percent ethanol. According to the method disclosed by the invention, vitamin D3 and xanthan gum are mixed with the ethanol so as to carry out granulating, the stability of prepared granules is effectively improved, and the problems that vitamin D3 is unqualified in authentication and non-uniform in content are solved, so that the quality of products is improved; the method is simple in process flow and is energy-saving and cost-saving, thereby being applicable to industrial production.

Description

technical field [0001] The invention belongs to the field of granules and preparation thereof, in particular to a calcium carbonate D3 granule and a preparation method thereof. Background technique [0002] With the rapid development of science and food industry, fortified foods are also increasing. Zinc, iron, and calcium are essential nutrients for the human body. Among them, calcium is one of the most common elements in the human body and is called "reinforced concrete in life." "The content of calcium in the human body accounts for 1.5--2% of the total body weight, of which bones and teeth account for about 99%. Body fluids and soft tissues make up 1%. It plays a vital role in human metabolism, cell function, nervous system operation, and protein hormone synthesis. Studies have shown that women with low calcium intake during pregnancy (an average of 478 mg per day) have a high intestinal absorption rate of calcium, but their bone density (represented by lumbar spine bo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/10A61K47/36A61K47/38A61K9/16A61P3/02A61K31/593
CPCA61K9/1652A61K31/593A61K33/10A61K2300/00
Inventor 刘景萍刘全国陈克领林文君
Owner HAINAN HULUWA PHARMA GRP CO LTD
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