Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of curcumin analog containing n-cyclopropane substitution and its pharmaceutical application

A technology of curcumin analogs and cyclopropane, which can be used in medical preparations containing active ingredients, drug combinations, antipyretics and other directions, and can solve problems such as affecting the therapeutic effect of patients and side effects.

Inactive Publication Date: 2017-11-07
WENZHOU MEDICAL UNIV
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, at present, there are certain side effects of steroidal and non-steroidal anti-inflammatory drugs used in the treatment or prevention of bacterial-induced sepsis and chemical-induced inflammatory reactions, which affect the therapeutic effect of patients.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of curcumin analog containing n-cyclopropane substitution and its pharmaceutical application
  • A kind of curcumin analog containing n-cyclopropane substitution and its pharmaceutical application
  • A kind of curcumin analog containing n-cyclopropane substitution and its pharmaceutical application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0016] refer to figure 1 , the molecular expression of the present invention containing the curcumin analogue that N-cyclopropane replaces is:

[0017] (3E,5E)-3-(3-allyl-4-hydroxybenzylidene)-1-cyclopropyl-5-(2,4-dimethoxybenzylidene)piperidine-4 - a ketone, (abbreviated as S8 in the following text).

[0018] The spectral data of the compound are as follows: yellow solid, the yield is 25%, and the melting point is 182.6°C-184.5°C; 1 H-NMR (600MH Z ,DMSO-d 6 ): δ=10.03(1H,s,Ar-OH),7.79(1H,s,H-β'),7.49(1H,s,H-β),7.24(1H,d,J=6.0Hz,H -6'),7.23(1H,d,J=7.8Hz,H-6),7.22(1H,s,H-2),6.69(1H,s,H-3'),6.92(1H,d, J=7.8Hz, H-5), 6.64 (1H, d, J=6.0Hz, H-5'), 6.02-5.95 (1H, m, A-ArCH 2 CH=CH 2 ),5.09-5.04(2H,m,A-ArCH 2 CH=CH 2 ),3.89(2H,s,A-ArCH 2 CH=CH 2 ),3.85(4H,s,piperidone-CH 2 -N-CH 2 ),3.83(6H,s,2',4'-OCH 3 ),1.97-1.94(1H,m,-N-CH-Cyclopropyl),0.45-0.42(2H,m,N-CH 2 -CH 2 -Cyclopropyl),0.26-0.23(2H,m,N-CH 2 -CH 2 -Cyclopropyl); 13 C-NMR (600MH Z ,DMSO-d 6 ):δ=186.07,1...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an N-cyclopropane substituent-containing curcumin analogue. The molecular expression of the curcumin analogue is (3E,5E)-3-(3-allyl-4-hydroxyl benzylidene)-1-cyclopropyl-5-(2,4-dimethoxy benzylidene)piperidine-4-ketone. The invention further discloses drug application of the N-cyclopropane substituent-containing curcumin analogue. The N-cyclopropane substituent-containing curcumin analogue is applied to prevention or treatment of sepses induced by bacteria and inflammatory reactions induced by chemical substances, wherein the sepses induced by the bacteria comprise inflammatory factor release induced by lipopolysaccharide (LPS) and septic death induced by the LPS, and the inflammatory reactions induced by the chemical substances comprise ear swelling induced by xylene, vascular permeability increasing caused by intraperitoneal injection of acetic acid and twisting number increasing caused by acetic acid.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, relates to a curcumin analog containing N-cyclopropane substitution, and also relates to a drug for treating or preventing sepsis induced by bacteria and inflammation induced by chemical substances by the curcumin analog application. Background technique [0002] Inflammation refers to various damaging changes in cells and tissues when exogenous and endogenous injury factors act on the body. At the same time, a series of complex reactions also occur locally and throughout the body to limit and eliminate injury factors, eliminate And this comprehensive body defense response that absorbs dead tissue and cells, and repairs the damage. Inflammatory response mediates the occurrence and development of various diseases and plays an important role in the progression of diseases. The inflammatory response is mostly manifested as the release of a large amount of pro-inflammatory facto...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07D213/68A61K31/451A61P31/04A61P29/00A61P27/16A61P9/14A61P43/00
CPCC07D213/68
Inventor 陈通克王丽花汤陌生
Owner WENZHOU MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com