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Vibrio mimicus OmpU adhesin protein binding peptide having adhesion antagonistic activity, polypeptide composition and application thereof

A technology of mimicking Vibrio and combining peptides, which can be used in medical preparations containing active ingredients, hybrid peptides, antibacterial drugs, etc. Effects of controlling fish ascites disease and reducing the virulence of Vibrio mimicus

Active Publication Date: 2015-12-09
ANHUI AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

At present, the main method of controlling fish ascites disease is antibacterial treatment, but with the long-term use of antibacterial drugs, bacteria develop drug resistance, which not only leads to ineffective treatment, but also affects the quality of aquatic products, and there are public health risks

Method used

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  • Vibrio mimicus OmpU adhesin protein binding peptide having adhesion antagonistic activity, polypeptide composition and application thereof
  • Vibrio mimicus OmpU adhesin protein binding peptide having adhesion antagonistic activity, polypeptide composition and application thereof
  • Vibrio mimicus OmpU adhesin protein binding peptide having adhesion antagonistic activity, polypeptide composition and application thereof

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Embodiment Construction

[0035] For ease of understanding, the present invention will be described in detail below through specific embodiments and accompanying drawings. It should be pointed out that these descriptions are only exemplary descriptions, and are not intended to limit the scope of the present invention.

[0036] The experimental methods described in the following instructions, unless otherwise specified, are conventional methods; the reagents and biological materials in the experimental methods, unless otherwise specified, can be obtained from commercial sources.

[0037] The percentages in the following descriptions are all mass percentages unless otherwise specified.

[0038] The ratios in the following descriptions are volume ratios unless otherwise specified.

[0039] 1. Affinity panning and identification of Vibrio mimicus OmpU adhesin binding peptides

[0040] 1.1 Affinity panning

[0041] With coating solution (pH8.6, 0.1mol / L NaHCO 3Solution) Dilute the purified recombinant O...

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Abstract

The invention relates to vibrio mimicus OmpU adhesin protein binding peptide having an adhesion antagonistic activity, a polypeptide composition and an application thereof. The vibrio mimicus OmpU adhesin protein binding peptide is composed of an amino sequence SEQ ID No.1, while the polypeptide composition is composed of three polypeptides: the SEQ ID No.1, the SEQ ID No.2 and the SEQ ID No.3, wherein the mass ratio of the three polypeptides represented as the SEQ ID No.1, the SEQ ID No.2 and the SEQ ID No.3 is 1:1:1. The vibrio mimicus OmpU adhesin protein binding peptide having the adhesion antagonistic activity and the polypeptide composition thereof not only can be specifically combined with OmpU adhesin protein but also can effectively inhibit that vibrio mimicus is adhered and immobilized on surface of intestinal mucosa through the adhesin, thereby eliminating toxicity of the vibrio mimicus. An adhesion antagonistic agent prepared from the OmpU adhesin protein binding peptide having the adhesion antagonistic activity and the polypeptide composition thereof can effectively prevent and treat fish ascites caused by the vibrio mimicus.

Description

technical field [0001] The present invention relates to polypeptides, polypeptide compositions and applications thereof, in particular to Vibrio mimetic OmpU adhesin protein-binding peptides with adhesion antagonistic activity, polypeptide compositions and applications thereof. Background technique [0002] Vibriomicus is a common enteric pathogen in aquaculture production. It mainly causes fish ascites disease through intestinal mucosal infection, which seriously threatens the healthy development of aquaculture industry. At present, the main method of controlling fish ascites disease is antibacterial treatment, but with the long-term use of antibacterial drugs, bacteria develop drug resistance, which not only leads to ineffective treatment, but also affects the quality of aquatic products, and there are public health risks. Therefore, there is an urgent need to develop new drugs against Vibrio mimic infection that do not produce drug resistance. Contents of the invention ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/08C07K19/00A61K38/04A61K38/10A61P31/04
Inventor 李槿年戚莉芳孔令严高会会侯立婷
Owner ANHUI AGRICULTURAL UNIVERSITY
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