Model-making method of hepatic stagnation and spleen deficiency type functional dyspepsia model for rats

Abstract

The invention discloses a model-making method of hepatic stagnation and spleen deficiency type functional dyspepsia model for rats, pertaining to fields of medical evaluation and detection technology. The model-making method is characterized in that after healthy Wistar male rats are subjected to electrode-embedding operation, simulation of each rat by clipping tails, overfatigue and operation for drinking and eating disorder can be carried out in order to perform composite model-making operation; by means of weight, electrophysiology activities, gastric emptying, intestine propulsion and objective detection of molecular biology, the purpose of complying a made hepatic stagnation and spleen deficiency type FD model and diagnostic criteria for a clinical hepatic stagnation and spleen deficiency type FD theory is fulfilled in order to achieve consistency of clinical and basic science study; and acquired animals of the hepatic stagnation and spleen deficiency type functional dyspepsia model have symptoms of dyspepsia without other organic pathologic changes.

Description

technical field [0001] The invention belongs to the technical field of medical evaluation and detection, and relates to a modeling method of an animal model, in particular to a modeling method of a rat model of liver depression and spleen deficiency type functional dyspepsia. Background technique [0002] Functional dyspepsia (FD) is a typical physical and mental disease. Psychological-social factors play an important role in the pathogenesis. Emotional, psychological, social and biological factors interact and participate in the occurrence of FD. In recent years, the incidence of FD has shown an increasing trend. Epidemiological surveys show that the prevalence in European and American countries is 20% to 25%, and that in Asian countries is about 8% to 23%. The prevalence of FD in my country is generally high A survey of 782 patients with dyspepsia symptoms over the age of 18 in Shanghai found that FD patients accounted for 69%. High morbidity and recurrent or chronic protr...

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Problems solved by technology

[0004] The above-mentioned existing studies on FD models of liver depression and spleen deficiency have many defects: the model making method is relatively simple, for example, a large number of literature reports are used to prepare the models of liver depression and spleen deficiency by using the tail pinching stimulation method of Guo Haijun et al.; some models lack The objective detection standard for modeling success is that the FD animal model simulated based on the theory of traditional Chinese medicine and the etiology of dyspepsia should meet the diagnostic criteria of FD. The FD model animal should not only have symptoms of dyspepsia but also have no other organs. In addition, there is a lack of comparative studies on the advantages and disadvantages of different modeling methods, and the specific group matching, as well as the success rate and mortality rate are unclear or not explained

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