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Non-creative scoring model for ULN chronic hepatitis B and hepatic fibrosis and establishment method therefor

A technology for hepatitis liver fibrosis and liver fibrosis, applied in the field of clinical medicine, achieving high sensitivity and accuracy, convenient operation, and simple method

Inactive Publication Date: 2015-08-26
何清
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Problems solved by technology

[0003] The purpose of the present invention is to provide a non-invasive scoring model of ULN chronic hepatitis B liver fibrosis and its establishment method, aiming to solve the problem that there is no diagnostic model technology for ALT<2 times ULN chronic hepatitis B liver fibrosis

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  • Non-creative scoring model for ULN chronic hepatitis B and hepatic fibrosis and establishment method therefor
  • Non-creative scoring model for ULN chronic hepatitis B and hepatic fibrosis and establishment method therefor
  • Non-creative scoring model for ULN chronic hepatitis B and hepatic fibrosis and establishment method therefor

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Embodiment Construction

[0014] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0015] The application principle of the present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

[0016] The ULN non-invasive scoring model for chronic hepatitis B liver fibrosis provided by the embodiments of the present invention selects 249 chronic hepatitis B patients with ALT0.259), and the scoring model DMFibroS was established.

[0017] Such as figure 1 The establishment method of the ULN chronic hepatitis B liver fibrosis non-invasive scoring model of the embodiment of the present invention comprises the following steps:

[0018] S101: Select 249 pa...

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Abstract

The present invention discloses a non-creative scoring model for ULN chronic hepatitis B and hepatic fibrosis and establishment method therefor. According to the non-creative scoring model for the ULN CHB and hepatic fibrosis, 249 chronic virus hepatitis B patients whose ALT is lower than twice of ULT are selected, clinical conventional indicators are screened, relevance between each indicator and hepatic fibrosis is analyzed one by one at a Spearman level, six indicators are selected from the indicators whose P is lower than 0.05, and r is greater than 0.259, and a scoring model DMFibroS is established; scores are obtained and accumulated by computing a relative ratio of each indicator, and diagnostic ability is evaluated and verified by using a working characteristic curve of subjects; area fluctuation under the working characteristic curve is determined to be from 0.660 to 0.777 upon diagnosis by analyzing subjects subjected to hepatic fibrosis based on the six indicators; and the DMFibroS model is established in combination of the six indicators. The method according to the present invention is simple, and the operation is convenient, which makes up for the margin of the industry.

Description

technical field [0001] The invention belongs to the technical field of clinical medicine, and in particular relates to a ULN chronic hepatitis B liver fibrosis non-invasive scoring model and a method for establishing the same. Background technique [0002] Obtaining pathological information through liver biopsy is an important means to guide patients with chronic hepatitis B with ALT <2 times ULN to start antiviral therapy, but the operation of liver biopsy is complicated, invasive and prone to complications, which restricts its wide application in clinical practice . In recent years, some scholars have begun to explore ways to understand liver tissue lesions by establishing a combined model of serological indicators, but so far there has been no report on a diagnostic model of liver fibrosis in chronic hepatitis B with ALT < 2 times ULN. Contents of the invention [0003] The purpose of the present invention is to provide a ULN chronic hepatitis B liver fibrosis no...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/00
Inventor 何清敖飞健白冰唐情容唐奇远廖雪娇何逸洲赖长祥李知玉张斌段钢丘利宜艾舒玲赵东熊怀燕
Owner 何清
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