Simultaneous determination method of vanillin, ethyl vanillin and coumarin in electronic cigarette liquid

Abstract

A simultaneous determination method for vanillin, ethyl vanillin and coumarin in electronic cigarette liquid, characterized in that: accurately weigh a certain amount of electronic cigarette liquid, dilute it with an organic solution containing an internal standard substance after oscillation , take 1mL of the solution into a 2mL chromatographic bottle, and simultaneously quantitatively analyze and detect the vanillin, ethyl vanillin and coumarin in the smoke liquid by gas chromatography-mass spectrometry / selected ion monitoring mode (GC-MS / SIM) content. The advantages of this method are that less sample volume and reagent consumption are required, simple and fast operation, high efficiency in a short time, high sensitivity of analysis and determination, and the detection limits of vanillin, ethyl vanillin and coumarin are respectively 0.03 μg / mL, 0.04μg / mL and 0.03μg / mL, the coefficients of variation of the determination results of vanillin, ethyl vanillin and coumarin were 1.9%, 3.3%, 4.2%, respectively, and the recovery rate was between 96% and 112%. The result is stable, the recovery rate is high, and the quantification is accurate.

Description

technical field [0001] The invention relates to a quantitative analysis method for vanillin, ethyl vanillin and coumarin in electronic cigarette liquid, and belongs to the field of tobacco chemistry. Background technique [0002] E-cigarette is a product that atomizes the e-cigarette solution through an atomizer to deliver nicotine and / or other substances to the respiratory system. Electronic cigarette liquid is an important part of electronic cigarettes, and electronic cigarette liquid includes synthetic liquid and natural liquid. The substances contained in the e-liquid mainly include nicotine / tobacco extract, solvents and flavors and fragrances. Among them, the use of flavors and fragrances is one of the important factors affecting the style characteristics and safety of electronic cigarette products. [0003] Coumarin, whose chemical name is 2H-1-benzopyran-2-one, is a light yellow viscous liquid. Coumarin is an aromatic compound widely present in nature, distributed i...

AI Technical Summary

Problems solved by technology

[0006] At present, some e-liquid products introduce coumarin due to the use of natural plant additives. Most e-liquid products generally use vanillin and ethyl vanillin as additives for vanilla-flavored e-liquid. There is no exact limit for the amount of additives, and these situations will bring safety hazards to e-cigarette liquid products

There is currently no literature on the quantitative analysis of coumarin, vanillin and ethyl vanillin in e-cigarette liquid

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