A microfluidic chip and method for preparing nanocapsules using it

Abstract

The invention relates to a micro-fluidic chip which comprises a first passage, a second passage, a third passage, a fourth passage, a fifth passage and a sixth passage e, wherein a first node, a second node and a third node are sequentially distributed on the first passage along forward flow, and the first passage is divided into a first sub passage and a second sub passage after the third node; the first sub passage and the second sub passage intersect at a fourth node to interflow to be an eighth passage; the second passage and the third passage are distributed on the two sides of the first passage, and are communicated with the first passage through the first node; the fourth passage and the fifth passage are distributed on the two sides of the first passage, and are communicated with the first passage through the second node; the sixth passage is communicated, at the fourth node, with the first sub passage, the second sub passage and the eighth passage. The micro-fluidic chip provided by the invention has a multistage structure, can be used for preparing hollow nano-particles with multistage core-shell structures, and achieves the possibility of packaging and loading different medicines.

Description

technical field [0001] The invention belongs to the field of microfluidic chip preparation, and relates to a microfluidic chip and a method for preparing nanocapsules by using the microfluidic chip. The microfluidic chip has a multi-level structure and can controllably synthesize general-purpose functional nanocapsules with stable structures. For the construction of nano-transportation system. Background technique [0002] Currently, nano-transport systems are developing rapidly. Nanoparticles are used as carriers to deliver drugs to specific cells or carry imaging agents to assist in imaging, which has greatly improved the efficacy of diseases, reduced the toxicity of drugs and adjuvants, and realized the concept of integrated diagnosis and treatment. Nanotechnology is widely used in disease diagnosis, treatment, prognosis and other aspects. [0003] At present, the entrapped delivery of drugs or other molecules usually requires the design of different carriers for drug m...

AI Technical Summary

Problems solved by technology

However, the disclosed microfluidic chip only has a two-stage structure, and the synthesized nanoparticles have a solid structure, which cannot meet the preparation requirements of the prior art for hollow nanoparticles.

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