Tandem time-of-flight mass spectrometry using non-uniform sampling

A time-of-flight mass spectrometry, tandem technology, applied in time-of-flight spectrometers, methods using particle spectrometers, mass spectrometers, etc.

Active Publication Date: 2017-01-18
LECO CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] In summary, the existing TOF-TOF tandem device has not yet achieved parallel "full mass" analysis while using high-resolution multi-reflection TOF analyzers at both stages

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  • Tandem time-of-flight mass spectrometry using non-uniform sampling
  • Tandem time-of-flight mass spectrometry using non-uniform sampling
  • Tandem time-of-flight mass spectrometry using non-uniform sampling

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Embodiment Construction

[0043] Figure 1-A An exemplary multiplexed tandem multiple reflection time-of-flight (MR-TOF) mass spectrometer 11 is shown. According to some implementations, the MR-TOF mass spectrometer 11 comprises a multiple reflection time-of-flight (MR-TOF) analyzer, which in turn has two parallel-aligned ion mirrors 12 (although planar here for the sake of explanation, can also be cylindrical), a drift space and a periodic lens 14 between the mirrors 12 . The MR-TOF mass spectrometer 11 also includes a pulsed ion source 15 , a multiplexing time selector 16 , a fragmentation unit 17 , a detector 18 and a non-redundant multiplexing data system 20 . Average ion trajectories for precursor ions are shown as solid lines 19P and average ion trajectories for fragment ions are shown as dashed lines 19F.

[0044] The pulsed ion source 15 may be, for example: (a) a radio frequency (RF) ion trap with radial or axial ion emission that traps ions or passes a continuous stream of ions at low ion en...

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Abstract

Methods and apparatus are disclosed for a total mass tandem mass spectrometer utilizing a multi-reflection time-of-flight analyzer for two MS stages preferably arranged within the same analyzer to ensure very high resolution . The sensitivity and speed of TOF‑TOF concatemers are enhanced by non-redundant multiplexing based on signal sparsity and avoiding overlapping of repetitive signals under multiple repetitions of real fragmented signals. Non-redundant matrices for gate and delay timing are constructed by expanding the orthogonal Latin square matrix. The method is generally applicable to the multiplexing of any number of repetitive signal sources that are spectrally, spatially or temporally sparse.

Description

[0001] Cross References to Related Applications [0002] This International Patent Application claims the benefit of US Provisional Application 61 / 661,268, filed June 18, 2012. The disclosure of this prior application is considered part of the disclosure of the present application and is hereby incorporated by reference in its entirety. technical field [0003] The present application relates generally to the field of mass spectrometry, and more particularly to improvements in the sensitivity, resolution, speed and / or dynamic range of tandem time-of-flight mass spectrometers. Background technique [0004] Tandem mass spectrometry (MS-MS) uses separation of precursor ions in a first mass spectrometer (MS1), fragmentation of the separated species, and mass analysis of the fragment ions in a second mass spectrometer (MS2) to Perform compound identification and structural studies. Current applications of tandem mass spectrometry in the life sciences encounter the challenge of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01J49/00H01J49/10H01J49/40
CPCH01J49/0027H01J49/0081H01J49/406H01J49/0031H01J49/005H01J49/10
Inventor A·N·维伦切考夫V·马卡洛夫
Owner LECO CORPORATION
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