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Guided tissue regeneration membrane as well as preparation method and application thereof

A technology for guiding tissue regeneration and double-layer membrane, which is used in chemical instruments and methods, medical science, cellulose plastic material layered products, etc. To achieve the effect of promoting the formation of new tissue, conducive to cell ingrowth, and wide clinical application

Active Publication Date: 2015-04-01
烟台蓝创生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invent describes an improved type of guide tissue replacement membrane called "guiding tissue renewable membrance." It consists of two layers - one made up mostly of raw materials like proteins from animal sources (collagens), which gradually break down over time into tiny particles. These small particles help create space between them inside each other, allowing blood vessel networks to develop around it instead of just filling its own holes. Overall, this design allows for more effective healing without causing inflammatory responses on adjacent areas.

Problems solved by technology

This patented technical problem addressed in this patent relates to developing effective methods for promoting healing of teeth without causing discomfort or requiring multiple procedures that could potentially harm healthy surrounding areas. Current techniques involve delivering therapeutic agents through traditional porous filters, but these tend to lose their effects over time due to breakdown caused by natural resorption. To solve this issue, researchers developed new ways to create temporary tubular structures called guiding tissues (GTR) on affected parts like roots. These GTR allow direct growth of connective tissue between root canal space and peripherals while still allowing blood vessels within the spaces to flow freely throughout the entirety of the treated part's volume. By designing different layers of material based on specific needs, less invasiveness, reduced risk of rejection compared to existing treatment options, and improved durability were possible.

Method used

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  • Guided tissue regeneration membrane as well as preparation method and application thereof
  • Guided tissue regeneration membrane as well as preparation method and application thereof
  • Guided tissue regeneration membrane as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1 A kind of preparation method of guided tissue regeneration film

[0047] 1. Dosing

[0048] Dissolve collagen and polylactic acid (PLA) in hexafluoroisopropanol (HFIP) according to the mass ratio of 1:9, and the ratio of material to liquid is 1:10, and stir until completely dissolved to obtain uniform spinning with a long degradation time Liquid(Z);

[0049] Dissolve collagen and polylactic acid (PLA) in hexafluoroisopropanol (HFIP) at a mass ratio of 9:1, with a material-to-liquid ratio of 1:10, and stir until completely dissolved to obtain uniform spinning with a short degradation time Liquid (Q).

[0050] 2. Spinning dense layer

[0051] Put the above spinning solution Z into the electrospinning syringe, adjust the rate of the micro-injection pump to 5ml / hour, the voltage of the electrospinning machine to 20KV, adjust the receiving distance of the receiving device to 20cm, and stop spinning after reaching a thickness of 0.1mm , quickly enter the next...

Embodiment 2

[0056] Embodiment 2 A kind of preparation method of guided tissue regeneration film

[0057] 1. Dosing

[0058] Dissolving gelatin and silk fibroin in trifluoroethanol at a mass ratio of 2:8, with a solid-liquid ratio of 1:20, stirring until completely dissolved to obtain a uniform spinning solution (Z) with a long degradation time;

[0059] Dissolve gelatin and silk fibroin in trifluoroethanol at a mass ratio of 8:2, with a solid-to-liquid ratio of 1:20, and stir until completely dissolved to obtain a uniform spinning solution (Q) with a short degradation time.

[0060] 2. Spinning dense layer

[0061] Put the above spinning solution Z into the electrospinning syringe, adjust the rate of the micro-injection pump to 0.5ml / hour, the voltage of the electrospinning machine to 10KV, adjust the receiving distance of the receiving device to 10cm, and stop spinning after reaching a thickness of 0.1mm. Silk, quickly enter the next step;

[0062] 3. Spinning potential loose layer

...

Embodiment 3

[0066] Embodiment 3 A kind of preparation method of guided tissue regeneration film

[0067] 1. Dosing

[0068] Chitosan and polylactic-glycolic acid (PLGA) are dissolved in formic acid according to the ratio of mass ratio 3:7, and the ratio of solid to liquid is 1:5, and stirred until completely dissolved to obtain a uniform spinning solution with a long degradation time (Z );

[0069] Chitosan and polylactic-glycolic acid (PLGA) are dissolved in formic acid according to the ratio of mass ratio 7:3, and the ratio of solid to liquid is 1:5, and stirred until completely dissolved to obtain a uniform spinning solution with a shorter degradation time (Q ).

[0070] 2. Spinning potential loose layer

[0071] The above-mentioned spinning solution Z and spinning solution Q are respectively packed in the electrospinning injectors Z and Q, the injection flow rate of the adjustment injector Z is 0.1ml / hour, and the ratio of the injection flow rate of the adjustment injector Q to the...

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Abstract

The invention discloses a guided tissue regeneration membrane. The membrane adopts a double-layer membrane structure and is characterized in that one layer is a compact layer prepared from biological fibers with longer degradation time, and the other layer is a potential loose layer prepared through mixing of biological fibers with different degradation time. After the potentialloose layer is implanted in a body, part of the biological fibers degrades quickly, so that the pore diameter of the membrane is increased, and ingrowth of cells is facilitated. The compact layer and the potential loose layer are connected through the same biological fibers with the longer degradation time, so that the double-layer membrane is free of splitting and fractures. The invention further discloses a preparation method of the guided tissue regeneration membrane as well as an application of the guided tissue regeneration membrane as a tissue repair product to tissue repair.

Description

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Claims

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Application Information

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Owner 烟台蓝创生物技术有限公司
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