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Tilmicosin soluble powder and preparation method thereof

A soluble powder, tilmicosin technology, applied in powder delivery, pharmaceutical formulations, organic active ingredients and other directions, can solve the problems of complex preparation process, turbid solution, limited application, etc., and achieves good solubility, broad application prospects, and preparation. simple craftsmanship

Active Publication Date: 2015-04-01
SHANGHAI TONGREN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology provides an improved version of tormosyn that can be easily prepared without expensive or complicated equipment. It also works well even at high temperatures over time because it contains no harmful chemical substances like sulfur dioxide (SO2) gas).

Problems solved by technology

Technological Problem: Current methods for producing butterimosunicolones involve complicated processes involving multiple steps like extraction, purification, crystallization, lyophilizing, drying, mixing them together into an emulsified liquid called nebulizers (which can also cause irritative symptoms). Additionally, current forms of these compounds require specific types of drugs like levamycins because they lack targeted delivery capabilities during systematic circulation within animals.

Method used

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  • Tilmicosin soluble powder and preparation method thereof
  • Tilmicosin soluble powder and preparation method thereof
  • Tilmicosin soluble powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Weigh each raw material with the following mass percentage (take the total amount as 100g as an example):

[0024]

[0025] Take 5 g of tilmicosin, 3 g of sodium dihydrogen phosphate, 1 g of pluronic F68, 3 g of PEG4000 and 88 g of glucose, mix them evenly, and grind to obtain tilmicosin soluble powder.

[0026] The obtained tilmicosin soluble powder was tested according to the content specified in the national standard compilation of veterinary drugs, including: traits, identification, loss on drying, appearance uniformity, solubility, and content; the specific results are shown in Table 1.

Embodiment 2

[0028] Weigh each raw material with the following mass percentage (take the total amount as 100g as an example):

[0029]

[0030] Take 15g of tilmicosin, 3g of citric acid, 1g of pluronic F685gPEG6000 and 78g of glucose, mix evenly, and grind to obtain the soluble powder of tilmicosin.

[0031] The obtained tilmicosin soluble powder was detected by the detection method described in Example 1, and the specific results are shown in Table 1.

Embodiment 3

[0033]

[0034] Take 25g of tilmicosin, 15g of phosphoric acid, 3g of Tween-808gPEG6000 and 49g of glucose, mix evenly, and grind to obtain tilmicosin soluble powder.

[0035] The obtained tilmicosin soluble powder was detected by the detection method described in Example 1, and the specific results are shown in Table 1.

[0036] Table 1

[0037]

[0038]

[0039] It can be seen from Table 1 that the tilmicosin soluble powder provided by the present invention is a white powder, and each quality inspection index meets the compilation of national standards for veterinary drugs. It has high solubility, conforms to regulations, and has stable performance.

[0040] Adopt tilmicosin soluble powder of the present invention and preparation method thereof, its preparation process is simple, simply mixes and gets final product, and raw material is all commercially available raw material, and cheap and easy to obtain, and the performance of gained compound preparation is stable...

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Abstract

The invention relates to a tilmicosin soluble powder. The tilmicosin soluble powder is characterized by comprising the following ingredients in percentage by mass: 5-25% of tilmicosin, 3-15% of a cosolvent, 1-3% of a solubilizer, 3-8% of PEG and filler. The invention further provides a preparation method of the tilmicosin soluble powder. According to the tilmicosin soluble powder and the preparation method thereof disclosed by the invention, the preparation process is simple, only simple mixing is needed, the raw materials are all commercially available, low in price and easily available, and the obtained compound preparation is stable in performance; because of addition of the cosolvent and the solubilizer, the tilmicosin soluble powder is good in dissolving property, quite suitable for applications in clinic aspects, capable of meeting the relevant provisions of pharmacopoeia, suitable for industrialized large-scale production, and quite wide in application prospect. The tilmicosin soluble powder has a high practical value.

Description

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Claims

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Application Information

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Owner SHANGHAI TONGREN PHARM CO LTD
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