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A method for surface modification of oil-soluble up-conversion fluorescent nanomaterials

A fluorescent nanomaterial and surface modification technology, which is applied in the field of surface modification to improve the water solubility of oil-soluble rare earth up-conversion fluorescent nanomaterials, can solve the problems of affecting the fluorescence of materials, instability, and generation of impurity materials, and achieves low biocompatibility. , good water solubility, low cytotoxicity

Inactive Publication Date: 2016-08-17
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] In order to solve the deficiencies in the prior art, the present invention provides a surface modification method for improving the water solubility of oil-soluble up-conversion fluorescent nanomaterials. The technical problem solved is that the existing surface modification method is complicated to operate and affects the fluorescence of the material. Impurities are generated after modification and the modified material is unstable

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  • A method for surface modification of oil-soluble up-conversion fluorescent nanomaterials
  • A method for surface modification of oil-soluble up-conversion fluorescent nanomaterials
  • A method for surface modification of oil-soluble up-conversion fluorescent nanomaterials

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Experimental program
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Embodiment 1

[0056] In this embodiment, the surface modification of oil-soluble up-conversion fluorescent nanomaterials is carried out according to the following steps:

[0057] a. Weigh 80mg NaYF 4 :Yb,Er,Nd@NaYF 4 : Nd (40nm) oil-soluble up-conversion fluorescent nanomaterial with core-shell structure is placed in a flask, and 3 mL of chloroform is added to disperse evenly to obtain solution A;

[0058] b. Add 10 mg mPEG to Solution A 2K -b-PEBEP 6K , stirred for 0.5h to obtain reaction solution B;

[0059] c. Add 40mL of deionized water to the reaction solution B, and stir for 0.5h to obtain the reaction solution C;

[0060] d. At 20°C, remove the chloroform in the reaction solution C to obtain the reaction solution D;

[0061] e. The reaction solution D was centrifuged at 10000 rpm for 10 min, and the obtained precipitate was dried, that is, the surface modification of the oil-soluble up-conversion fluorescent nanomaterial was completed, and the water-soluble up-conversion fluores...

Embodiment 2

[0067]In this embodiment, the surface modification of oily upconversion nanoparticles is carried out according to the following steps:

[0068] a. Weigh 169mg NaYF 4 : Yb, Er (18nm) oil-soluble up-conversion nanoparticles in a flask, add 10mL of chloroform, and disperse evenly to obtain solution A;

[0069] b. Add 10 mg mPEG to Solution A 2K -b-PEBEP 6K , stirred for 1h to obtain reaction solution B;

[0070] c. Add 100 mL of deionized water to the reaction solution B, and stir for 2 hours to obtain the reaction solution C;

[0071] d. At 40°C, remove the chloroform in the reaction solution C to obtain the reaction solution D;

[0072] e. The reaction solution D was centrifuged at 14600 rpm for 20 minutes, and the obtained precipitate was dried, that is, the surface modification of the oil-soluble up-conversion fluorescent nanomaterial was completed, and the water-soluble up-conversion fluorescent nanomaterial was obtained.

[0073] Characterized by a fluorescence spectro...

Embodiment 3

[0075] In this embodiment, the surface modification of oily upconversion nanoparticles is carried out according to the following steps:

[0076] a. Weigh 60mg NaYF 4 : Yb, Er, Nd (34nm) oil-soluble up-conversion nanoparticles in a flask, add 4mL cyclohexane, and disperse evenly to obtain solution A;

[0077] b. Add 10 mg mPEG to Solution A 2K -b-PEBEP 6K , stirred for 1h to obtain reaction solution B;

[0078] c. Add 60 mL of deionized water to the reaction solution B, and stir for 2 hours to obtain the reaction solution C;

[0079] d. At 40°C, remove the cyclohexane in the reaction solution C to obtain the reaction solution D;

[0080] e. The reaction solution D was centrifuged at 12000 rpm for 10 min, and the obtained precipitate was dried, that is, the surface modification of the oil-soluble up-conversion fluorescent nanomaterial was completed, and the water-soluble up-conversion fluorescent nanomaterial was obtained.

[0081] Characterized by the fluorescence spectrom...

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Abstract

The invention discloses a surface modification method of an oil-soluble upconversion luminescent nanometer material. The surface modification method of the oil-soluble upconversion luminescent nanometer material is characterized by comprising the following steps: uniformly dispersing the oil-soluble upconversion luminescent nanometer material in an organic solvent, then adding mPEG2k-b-PEBEP6K and stirring; then heating to remove the organic solvent and finally, centrifugally separating to obtain precipitate, drying the precipitate, namely completing the surface modification of the oil-soluble upconversion luminescent nanometer material to obtain the oil-soluble upconversion luminescent nanometer material. The surface modification method of the oil-soluble upconversion luminescent nanometer material is characterized by simply stirring and centrifugally separating to obtain a nanomaterial with excellent water solubility; meanwhile, the nanomaterial is high in dispersion in a buffering solution similar to the biosystem.

Description

technical field [0001] The invention relates to the technical field of surface modification of nanomaterials, in particular to a surface modification method for improving the water solubility of oil-soluble rare earth up-conversion fluorescent nanomaterials. Background technique [0002] Rare-earth upconversion fluorescent nanomaterials have attracted much attention in recent years due to their low toxicity, long fluorescence lifetime, and strong biological penetration depth. They have great application potential in biological fields such as photodynamic therapy, biological imaging, and drug release. However, due to the relatively mature method of synthesizing up-conversion fluorescent nanomaterials with stable, consistent appearance and high luminous intensity at present, the organic oil phase (oleic acid, 1-octadecene) is used as the medium, so the prepared nanomaterials do not have The properties of hydrophilicity and biocompatibility limit its application in related biol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/02C09K11/85B82Y20/00B82Y30/00
Inventor 钱海生彭煌用刘坤杨显珠马寅初
Owner HEFEI UNIV OF TECH
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